ID   NCI-H1334
AC   CVCL_3971
SY   H1334; H-1334
DR   BTO; BTO:0003011
DR   EFO; EFO_0003117
DR   ATCC; CRL-5863
DR   Cosmic; 844596
DR   Cosmic; 877419
DR   Cosmic; 903586
DR   Cosmic; 980972
DR   Cosmic; 1032444
DR   Cosmic; 1152509
DR   Cosmic; 1891888
DR   IARC_TP53; 488
DR   KCLB; 91334
DR   Wikidata; Q54907791
RX   PubMed=1311061;
RX   PubMed=2386953;
RX   PubMed=8806092;
RX   PubMed=11030152;
RX   PubMed=31803961;
CC   Problematic cell line: Probably contaminated. The STR profile is identical to that of the NCI-H322 cell line. Originally thought to originate from a 56 year old male patient with a large cell lung carcinoma.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu224Asp (c.672G>C); ClinVar=VCV001493447; Zygosity=Unspecified (PubMed=1311061).
CC   Discontinued: ATCC; CRL-5863; true.
CC   Derived from sampling site: Lung. Cell type=Club cell.
ST   Source(s): ATCC; PubMed=11416159
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 12
ST   D16S539: 11,12
ST   D18S51: 17
ST   D21S11: 28
ST   D5S818: 11
ST   D7S820: 11
ST   D8S1179: 12,15
ST   FGA: 22
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C2923; Minimally invasive lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1556 ! NCI-H322
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 21-03-23; Version: 19
RX   PubMed=1311061;
RA   Mitsudomi T., Steinberg S.M., Nau M.M., Carbone D., D'Amico D.,
RA   Bodner S., Oie H.K., Linnoila R.I., Mulshine J.L., Minna J.D.,
RA   Gazdar A.F.;
RT   "p53 gene mutations in non-small-cell lung cancer cell lines and their
RT   correlation with the presence of ras mutations and clinical
RT   features.";
RL   Oncogene 7:171-180(1992).
RX   PubMed=2386953;
RA   Gazdar A.F., Linnoila R.I., Kurita Y., Oie H.K., Mulshine J.L.,
RA   Clark J.C., Whitsett J.A.;
RT   "Peripheral airway cell differentiation in human lung cancer cell
RT   lines.";
RL   Cancer Res. 50:5481-5487(1990).
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P.,
RA   McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr.,
RA   Carney D.N., Minna J.D., Mulshine J.L.;
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. 63 Suppl. 24:32-91(1996).
RX   PubMed=11030152; DOI=10.1038/sj.onc.1203815;
RA   Modi S., Kubo A., Oie H., Coxon A.B., Rehmatulla A., Kaye F.J.;
RT   "Protein expression of the RB-related gene family and SV40 large T
RT   antigen in mesothelioma and lung cancer.";
RL   Oncogene 19:4632-4639(2000).
RX   PubMed=31803961; DOI=10.1002/jcb.29564;
RA   Mulshine J.L., Ujhazy P., Antman M., Burgess C.M., Kuzmin I.,
RA   Bunn P.A. Jr., Johnson B.E., Roth J.A., Pass H.I., Ross S.M.,
RA   Aldige C.R., Wistuba I.I., Minna J.D.;
RT   "From clinical specimens to human cancer preclinical models -- a journey
RT   the NCI-cell line database-25 years later.";
RL   J. Cell. Biochem. 121:3986-3999(2020).