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Cellosaurus OVCAR-2 (CVCL_3941)

[Text version]
Cell line name OVCAR-2
Synonyms NIH:OVCAR-2; OVCAR2; OVCAR 2
Accession CVCL_3941
Resource Identification Initiative To cite this cell line use: OVCAR-2 (RRID:CVCL_3941)
Comments Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Disease Ovarian carcinoma (NCIt: C4908)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_6861 (Caov-2)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=22710073

Markers:
AmelogeninX
CSF1PO12
D2S133817,26
D3S135816
D5S81811
D7S82010
D8S117910,14
D13S31711
D16S53913
D18S5112,16
D19S43313
D21S1131
FGA22
TH019
TPOX8
vWA17

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Publications

PubMed=6372095; DOI=10.1126/science.6372095
Rogan A.M., Hamilton T.C., Young R.C., Klecker R.W. Jr., Ozols R.F.
Reversal of adriamycin resistance by verapamil in human ovarian cancer.
Science 224:994-996(1984)

PubMed=6385258
Hamilton T.C., Young R.C., Ozols R.F.
Experimental model systems of ovarian cancer: applications to the design and evaluation of new treatment approaches.
Semin. Oncol. 11:285-298(1984)

PubMed=3930572; DOI=10.1172/JCI112082
Pirker R., FitzGerald D.J.P., Hamilton T.C., Ozols R.F., Laird W.J., Frankel A.E., Willingham M.C., Pastan I.
Characterization of immunotoxins active against ovarian cancer cell lines.
J. Clin. Invest. 76:1261-1267(1985)

PubMed=2307530; DOI=10.1002/ijc.2910450306
Schilder R.J., Hall L., Monks A., Handel L.M., Fornace A.J. Jr., Ozols R.F., Fojo A.T., Hamilton T.C.
Metallothionein gene expression and resistance to cisplatin in human ovarian cancer.
Int. J. Cancer 45:416-422(1990)

PubMed=1348364; DOI=10.1073/pnas.89.7.3070
Godwin A.K., Meister A., O'Dwyer P.J., Huang C.-S., Hamilton T.C., Anderson M.E.
High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.
Proc. Natl. Acad. Sci. U.S.A. 89:3070-3074(1992)

PubMed=9041185
Johnson S.W., Laub P.B., Beesley J.S., Ozols R.F., Hamilton T.C.
Increased platinum-DNA damage tolerance is associated with cisplatin resistance and cross-resistance to various chemotherapeutic agents in unrelated human ovarian cancer cell lines.
Cancer Res. 57:850-856(1997)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_3941
Anatomy/cell type resources BTO; BTO:0002560
Encyclopedic resources Wikidata; Q54937004
Gene expression databases GEO; GSM185133
GEO; GSM185134
GEO; GSM711707
GEO; GSM851933
GEO; GSM1340586
GEO; GSM1341131
Polymorphism and mutation databases Progenetix; CVCL_3941
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number17