ID   T24T SLT4
AC   CVCL_3922
SY   SLT4; SL4
DR   BTO; BTO:0004892
DR   cancercelllines; CVCL_3922
DR   GEO; GSM136257
DR   Wikidata; Q54971478
RX   PubMed=19147813;
RX   PubMed=24376083;
RX   PubMed=29732388;
CC   Part of: BLA-40 bladder carcinoma cell line panel.
CC   Population: Caucasian; Swedish.
CC   Characteristics: Forms metastasis in the liver of mice. Produced by passage of the parent cell line through nude mice.
CC   Sequence variation: Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
CC   Omics: Exosome proteome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_RN65 ! T24T SL3
SX   Female
AG   82Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 16
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RX   PubMed=19147813; DOI=10.2353/ajpath.2009.080538;
RA   Smith S.C., Nicholson B., Nitz M.D., Frierson H.F. Jr., Smolkin M.,
RA   Hampton G.M., El-Rifai W., Theodorescu D.;
RT   "Profiling bladder cancer organ site-specific metastasis identifies
RT   LAMC2 as a novel biomarker of hematogenous dissemination.";
RL   Am. J. Pathol. 174:371-379(2009).
//
RX   PubMed=24376083; DOI=10.1002/pmic.201300452;
RA   Jeppesen D.K., Nawrocki A., Jensen S.G., Thorsen K., Whitehead B.,
RA   Howard K.A., Dyrskjot L., Orntoft T.F., Larsen M.R., Ostenfeld M.S.;
RT   "Quantitative proteomics of fractionated membrane and lumen exosome
RT   proteins from isogenic metastatic and nonmetastatic bladder cancer
RT   cells reveal differential expression of EMT factors.";
RL   Proteomics 14:699-712(2014).
//
RX   PubMed=29732388; DOI=10.3233/BLC-180167;
RA   Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.;
RT   "Systematic review: characteristics and preclinical uses of bladder
RT   cancer cell lines.";
RL   Bladder Cancer 4:169-183(2018).
//