ID   A818-4
AC   CVCL_3892
AS   CVCL_0128
SY   A-818-4; A 818-4; A818.4; A818 4; A8184; 818-4; 818_4; 818.4; 8184
DR   MCCL; MCC:0000020
DR   cancercelllines; CVCL_3892
DR   Cosmic; 710850
DR   Cosmic; 736267
DR   Cosmic; 808168
DR   Cosmic; 933525
DR   Cosmic; 1108342
DR   Cosmic; 1320466
DR   Wikidata; Q54607225
RX   PubMed=1764370;
RX   PubMed=1906154;
RX   PubMed=8426738;
RX   PubMed=8430098;
RX   PubMed=9472115;
RX   PubMed=10415853;
RX   PubMed=11787853;
RX   PubMed=12692724;
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=11787853).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Arg (c.34G>C); ClinVar=VCV000012579; Zygosity=Unspecified (PubMed=8426738; PubMed=11787853).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_3890 ! A818
SX   Female
AG   75Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 19
//
RX   PubMed=1764370; DOI=10.1038/bjc.1991.467; PMCID=PMC1977874;
RA   Barton C.M., Staddon S.L., Hughes C.M., Hall P.A., O'Sullivan C.,
RA   Kloppel G., Theis B., Russell R.C.G., Neoptolemos J., Williamson R.C.N.,
RA   Lane D.P., Lemoine N.R.;
RT   "Abnormalities of the p53 tumour suppressor gene in human pancreatic
RT   cancer.";
RL   Br. J. Cancer 64:1076-1082(1991).
//
RX   PubMed=1906154;
RA   Kalthoff H., Roeder C., Humburg I., Thiele H.-G., Greten H.,
RA   Schmiegel W.H.;
RT   "Modulation of platelet-derived growth factor A- and B-chain/c-sis
RT   mRNA by tumor necrosis factor and other agents in adenocarcinoma
RT   cells.";
RL   Oncogene 6:1015-1021(1991).
//
RX   PubMed=8426738;
RA   Kalthoff H., Schmiegel W.H., Roeder C., Kasche D., Schmidt A., Lauer G.,
RA   Thiele H.-G., Honold G., Pantel K., Riethmuller G., Scherer E.,
RA   Maurer J., Maacke H., Deppert W.;
RT   "p53 and K-RAS alterations in pancreatic epithelial cell lesions.";
RL   Oncogene 8:289-298(1993).
//
RX   PubMed=8430098; DOI=10.1073/pnas.90.3.863; PMCID=PMC45770;
RA   Schmiegel W.H., Roeder C., Schmielau J., Rodeck U., Kalthoff H.;
RT   "Tumor necrosis factor alpha induces the expression of transforming
RT   growth factor alpha and the epidermal growth factor receptor in human
RT   pancreatic cancer cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:863-867(1993).
//
RX   PubMed=9472115; DOI=10.3892/ijo.12.3.717;
RA   Muller C., Grosse Bockhorn A.C., Klusmeier S., Kiehl M., Roeder C.,
RA   Kalthoff H., Koch O.M.;
RT   "Lovastatin inhibits proliferation of pancreatic cancer cell lines
RT   with mutant as well as with wild-type K-ras oncogene but has
RT   different effects on protein phosphorylation and induction of
RT   apoptosis.";
RL   Int. J. Oncol. 12:717-723(1998).
//
RX   PubMed=10415853; DOI=10.1111/j.1749-6632.1999.tb09512.x;
RA   Lehnert L., Trost H., Schmiegel W.H., Roeder C., Kalthoff H.;
RT   "Hollow-spheres: a new model for analyses of differentiation of
RT   pancreatic duct epithelial cells.";
RL   Ann. N. Y. Acad. Sci. 880:83-93(1999).
//
RX   PubMed=11787853; DOI=10.1007/s004280100474;
RA   Moore P.S., Sipos B., Orlandini S., Sorio C., Real F.X., Lemoine N.R.,
RA   Gress T.M., Bassi C., Kloppel G., Kalthoff H., Ungefroren H.,
RA   Lohr J.-M., Scarpa A.;
RT   "Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras,
RT   p53, p16 and DPC4/Smad4.";
RL   Virchows Arch. 439:798-802(2001).
//
RX   PubMed=12692724; DOI=10.1007/s00428-003-0784-4;
RA   Sipos B., Moser S., Kalthoff H., Torok V., Lohr J.-M., Kloppel G.;
RT   "A comprehensive characterization of pancreatic ductal carcinoma cell
RT   lines: towards the establishment of an in vitro research platform.";
RL   Virchows Arch. 442:444-452(2003).
//