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Cellosaurus SW1736 (CVCL_3883)

[Text version]
Cell line name SW1736
Synonyms SW-1736; SW 1736
Accession CVCL_3883
Resource Identification Initiative To cite this cell line use: SW1736 (RRID:CVCL_3883)
Comments From: Scott and White Clinic; Temple; USA.
Omics: Deep phosphoproteome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=23833040; PubMed=30737244).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=23833040; PubMed=30737244).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln192Ter (c.574C>T); ClinVar=VCV000406579; Zygosity=Homozygous (PubMed=30737244).
  • Mutation; HGNC; 12373; TSHR; Simple; p.Ile486Phe (c.1456A>T); Zygosity=Heterozygous (PubMed=30737244).
Disease Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_IY89 (SW1736 eGFP-H2B)
Sex of cell Female
Age at sampling 77Y
Category Cancer cell line
STR profile Source(s): CLS=300453; PubMed=17465858; PubMed=18713817; PubMed=21868764; PubMed=25365311; PubMed=30737244

Markers:
AmelogeninX
CSF1PO12
D3S135816,17 (CLS=300453; PubMed=18713817; PubMed=30737244)
17,18 (PubMed=17465858)
D5S81812,13
D7S8208 (PubMed=17465858)
8,11 (CLS=300453; PubMed=18713817; PubMed=21868764; PubMed=25365311; PubMed=30737244)
D8S117913 (CLS=300453)
13,14 (PubMed=17465858; PubMed=18713817; PubMed=30737244)
D13S31711,12
D16S53911,12
D18S5114
D21S1129,31 (CLS=300453; PubMed=18713817; PubMed=30737244)
29,31.2 (PubMed=17465858)
FGA22
Penta D12
Penta E11,17
TH016 (CLS=300453; PubMed=21868764)
6,9.3 (PubMed=25365311; PubMed=30737244)
TPOX11
vWA16,19

Run an STR similarity search on this cell line
Publications

PubMed=6220172
Dracopoli N.C., Fogh J.
Polymorphic enzyme analysis of cultured human tumor cell lines.
J. Natl. Cancer Inst. 70:469-476(1983)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=14522906
Frasca F., Vella V., Aloisi A., Mandarino A., Mazzon E., Vigneri R., Vigneri P.
p73 tumor-suppressor activity is impaired in human thyroid cancer.
Cancer Res. 63:5829-5837(2003)

PubMed=17465858; DOI=10.1089/thy.2006.0246
Lee J.-J., Foukakis T., Hashemi J., Grimelius L., Heldin N.-E., Wallin G., Rudduck C., Lui W.-O., Hoog A., Larsson C.
Molecular cytogenetic profiles of novel and established human anaplastic thyroid carcinoma models.
Thyroid 17:289-301(2007)

PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569
Schweppe R.E., Klopper J.P., Korch C.T., Pugazhenthi U., Benezra M., Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A. 3rd, Smallridge R.C., Haugen B.R.
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971
Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=24825855; DOI=10.1158/1535-7163.MCT-13-0938
Parker R., Clifton-Bligh R., Molloy M.P.
Phosphoproteomics of MAPK inhibition in BRAF-mutated cells and a role for the lethal synergism of dual BRAF and CK2 inhibition.
Mol. Cancer Ther. 13:1894-1906(2014)

PubMed=25365311; DOI=10.1210/jc.2014-2359; PMCID=PMC4318896
Garg M., Okamoto R., Nagata Y., Kanojia D., Venkatesan S., Anand M.T., Braunstein G.D., Said J.W., Doan N.B., Ho Q., Akagi T., Gery S., Liu L.-Z., Tan K.T., Chang W.J., Yang H.H., Ogawa S., Koeffler H.P.
Establishment and characterization of novel human primary and metastatic anaplastic thyroid cancer cell lines and their genomic evolution over a year as a primagraft.
J. Clin. Endocrinol. Metab. 100:725-735(2015)

PubMed=26958598; DOI=10.1016/j.dib.2015.09.030; PMCID=PMC4773363
Ikeda K., Tachibana T., Suzuki Y., Fujioka K., Takeyama H., Manome Y.
Abnormal number cell division of human thyroid anaplastic carcinoma cell line, SW 1736.
Data Brief 5:396-398(2015)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C., Copland J.A. 3rd, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references
Cell line collections (Providers) CLS; 300453
IBRC; C10311
Cell line databases/resources cancercelllines; CVCL_3883
Anatomy/cell type resources BTO; BTO:0001611
Chemistry resources ChEMBL-Cells; CHEMBL3307699
ChEMBL-Targets; CHEMBL614773
PubChem_Cell_line; CVCL_3883
Encyclopedic resources Wikidata; Q29964497
Experimental variables resources EFO; EFO_0022676
Polymorphism and mutation databases Cosmic; 886549
Cosmic; 1068627
Cosmic; 1239961
Cosmic; 1280048
Cosmic; 1507375
Cosmic; 1533551
Cosmic; 1536128
Cosmic; 1889006
Cosmic; 2050366
Cosmic; 2054081
Cosmic; 2319853
Cosmic; 2786689
Cosmic; 2791084
IARC_TP53; 27015
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number31