ID   MA-104
AC   CVCL_3845
SY   Ma-104; MA 104; MA104; Microbiological Associates-104
DR   BTO; BTO:0004983
DR   CLO; CLO_0007492
DR   CLO; CLO_0007494
DR   CLO; CLO_0051423
DR   CLDB; cl3324
DR   CLDB; cl3325
DR   CLDB; cl3326
DR   CLDB; cl3327
DR   ATCC; CRL-2378
DR   BCRJ; 0157
DR   BioSample; SAMN03152038
DR   CCRID; 4201MON-CCTCC00041
DR   CLS; 305007
DR   ECACC; 85102918
DR   GEO; GSM758845
DR   GEO; GSM758846
DR   GEO; GSM758847
DR   GEO; GSM758848
DR   GEO; GSM758849
DR   GEO; GSM758850
DR   GEO; GSM758851
DR   GEO; GSM758852
DR   GEO; GSM758853
DR   GEO; GSM758854
DR   GEO; GSM758855
DR   GEO; GSM758856
DR   GEO; GSM758857
DR   GEO; GSM758858
DR   GEO; GSM758859
DR   KCB; KCB 2010001YJ
DR   NCBI_Iran; C486
DR   RCB; RCB0994
DR   Wikidata; Q54903682
RX   PubMed=4043530;
RX   PubMed=4626908;
RX   PubMed=16494729;
RX   PubMed=19941903;
RX   PubMed=20143388;
RX   PubMed=26235236;
RX   PubMed=28046048;
RX   PubMed=33389257;
RX   PubMed=34737324;
CC   Group: Non-human primate cell line.
CC   Problematic cell line: Misidentified. Originally thought to be of Rhesus macaque origin but found to be from African Green monkey (PubMed=4043530; PubMed=20143388) and more precisely from Chlorocebus pygerythrus (PubMed=34737324).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00077.
CC   Virology: Susceptible to infection by many viruses (arboviruses, reoviruses, rotaviruses, etc.).
CC   Virology: Susceptible to infection by SARS coronavirus (SARS-CoV) (PubMed=16494729).
CC   Virology: Susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257).
CC   Discontinued: ATCC; CRL-2378; true.
CC   Derived from sampling site: Fetal kidney.
OX   NCBI_TaxID=60710; ! Chlorocebus pygerythrus (Vervet monkey)
SX   Sex unspecified
AG   Fetus
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 21-03-23; Version: 28
RX   PubMed=4043530;
RA   Whitaker A.M., Hayward C.J.;
RT   "The characterization of three monkey kidney cell lines.";
RL   Dev. Biol. Stand. 60:125-131(1985).
RX   PubMed=4626908; DOI=10.1128/am.24.1.62-69.1972;
RA   Myers M.G., Vincent M.M., Hensen S.A., Tauraso N.M.;
RT   "Problems in the laboratory isolation of simian hemorrhagic fever
RT   viruses and isolation of the agent responsible for the Sussex-69
RT   epizootic.";
RL   Appl. Microbiol. 24:62-69(1972).
RX   PubMed=16494729; DOI=10.3201/eid1201.050496;
RA   Kaye M., Druce J., Tran T., Kostecki R., Chibo D., Morris J.,
RA   Catton M., Birch C.;
RT   "SARS-associated coronavirus replication in cell lines.";
RL   Emerg. Infect. Dis. 12:128-133(2006).
RX   PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022;
RA   Karger A., Bettin B., Lenk M., Mettenleiter T.C.;
RT   "Rapid characterisation of cell cultures by matrix-assisted laser
RT   desorption/ionisation mass spectrometric typing.";
RL   J. Virol. Methods 164:116-121(2010).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
RX   PubMed=26235236; DOI=10.1016/j.jviromet.2015.07.016;
RA   Otto P.H., Reetz J., Eichhorn W., Herbst W., Elschner M.C.;
RT   "Isolation and propagation of the animal rotaviruses in MA-104
RT   cells -- 30 years of practical experience.";
RL   J. Virol. Methods 223:88-95(2015).
RX   PubMed=28046048; DOI=10.1371/journal.pone.0169391;
RA   Dotti S., Lombardo T., Villa R., Cacciamali A., Zanotti C.,
RA   Andreani N.A., Cinotti S., Ferrari M.;
RT   "Transformation and tumorigenicity testing of simian cell lines and
RT   evaluation of poliovirus replication.";
RL   PLoS ONE 12:E0169391-E0169391(2017).
RX   PubMed=33389257; DOI=10.1007/s10096-020-04106-0;
RA   Wurtz N., Penant G., Jardot P., Duclos N., La Scola B.;
RT   "Culture of SARS-CoV-2 in a panel of laboratory cell lines,
RT   permissivity, and differences in growth profile.";
RL   Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021).
RX   PubMed=34737324; DOI=10.1038/s41598-021-00779-5;
RA   Lung O., Candlish R., Nebroski M., Kruckiewicz P., Buchanan C.,
RA   Moniwa M.;
RT   "High-throughput sequencing for species authentication and
RT   contamination detection of 63 cell lines.";
RL   Sci. Rep. 11:21657-21657(2021).