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Cellosaurus THLE-2 (CVCL_3803)

[Text version]
Cell line name THLE-2
Synonyms THLE2; Transformed Human Liver Epithelial-2
Accession CVCL_3803
Resource Identification Initiative To cite this cell line use: THLE-2 (RRID:CVCL_3803)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10149.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Adult
Category Transformed cell line
STR profile Source(s): AddexBio=T0015001/4912; ATCC=CRL-2706; IZSLER=BS CL 194

Markers:
AmelogeninX,Y
CSF1PO11,13
D2S133817,23
D3S135814,15
D5S81811,13
D7S82010,12
D8S117913
D13S3178,12
D16S53911,13
D18S5113,16
D19S43314
D21S1130,32.2
FGA22,24
Penta D10,13
Penta E12,13
TH017,9.3
TPOX8,11
vWA16,17

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Publications

DOI=10.1007/978-1-4612-0411-4_31
Lechner J.F., Smoot D.T., Pfeifer A.M.A., Cole K.H., Weston A., Groopman J.D., Shields P.G., Tokiwa T., Harris C.C.
A non-tumorigenic human liver epithelial cell culture model for chemical and biological carcinogenesis investigations.
(In book chapter) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.307-321; Humana Press; New York; USA (1990)

PubMed=7685115; DOI=10.1073/pnas.90.11.5123; PMCID=PMC46667
Pfeifer A.M.A., Cole K.E., Smoot D.T., Weston A., Groopman J.D., Shields P.G., Vignaud J.-M., Juillerat M., Lipsky M.M., Trump B.F., Lechner J.F., Harris C.C.
Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens.
Proc. Natl. Acad. Sci. U.S.A. 90:5123-5127(1993)

PubMed=8504475; DOI=10.1093/carcin/14.5.833
Lehman T.A., Modali R.V., Boukamp P., Stanek J., Bennett W.P., Welsh J.A., Metcalf R.A., Stampfer M.R., Fusenig N.E., Rogan E.M., Harris C.C.
p53 mutations in human immortalized epithelial cell lines.
Carcinogenesis 14:833-839(1993)

Patent=US5529920
Cole K.H., Lechner J.F., Reddel R.R., Harris C.C., Pfeifer A.M.A.
Human liver epithelial cell line and culture media therefor.
Patent number US5529920, 25-Jun-1996

Patent=US5759765
Harris C.C., Cole K.H., Lechner J.F., Reddel R.R.
Human liver epithelial cell lines.
Patent number US5759765, 02-Jun-1998

PubMed=23887712; DOI=10.1038/ncomms3218; PMCID=PMC3731665
Nault J.-C., Mallet M., Pilati C., Calderaro J., Bioulac-Sage P., Laurent C., Laurent A., Cherqui D., Balabaud C., Zucman-Rossi J.
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
Nat. Commun. 4:2218.1-2218.7(2013)

Cross-references
Cell line collections (Providers) AddexBio; T0015001/4912
ATCC; CRL-2706
IZSLER; BS CL 194
Cell line databases/resources CLO; CLO_0009346
Biological sample resources BioSample; SAMN03471297
Chemistry resources ChEMBL-Cells; CHEMBL4295456
ChEMBL-Targets; CHEMBL4296500
PubChem_Cell_line; CVCL_3803
Encyclopedic resources Wikidata; Q54972310
Polymorphism and mutation databases Cosmic; 2162542
IARC_TP53; 23553
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number25