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Cellosaurus MeT-5A (CVCL_3749)

[Text version]
Cell line name MeT-5A
Synonyms MeT 5A; MeT5A; Met5A; MET5A; Mesothelial cells transfected with pRSV-T 5A
Accession CVCL_3749
Resource Identification Initiative To cite this cell line use: MeT-5A (RRID:CVCL_3749)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-9444.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; SV40 large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pRSV-T).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Lung, pleura; UBERON=UBERON_0000977.
Cell type: Mesothelial cell; CL=CL_0000077.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_LJ67 (MeT-5A/EJ-ras)
Sex of cell Male
Age at sampling Adult
Category Transformed cell line
STR profile Source(s): ATCC=CRL-9444; IZSLER=BS CL 214

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133818,19
D3S135817,18
D5S81812
D7S82010
D8S117912,13
D13S31711,13
D16S53912
D18S5115,23
D19S43315
D21S1131.2
FGA22,23
Penta D10,11
Penta E10,16
TH016,9.3
TPOX8 (ATCC=CRL-9444)
8,11 (IZSLER=BS CL 214)
vWA15,18

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/MeT-5a
Publications

Patent=US4885238
Reddel R.R., Yang K., Rhim J.S., Brash D.E., Su R.T., Lechner J.F., Gerwin B.I., Harris C.C., Amstad P.A.
Immortalized human bronchial epithelial mesothelial cell lines.
Patent number US4885238, 05-Dec-1989

PubMed=2541616; PMCID=PMC1879894
Ke Y., Reddel R.R., Gerwin B.I., Reddel H.K., Somers A.N.A., McMenamin M.G., LaVeck M.A., Stahel R.A., Lechner J.F., Harris C.C.
Establishment of a human in vitro mesothelial cell model system for investigating mechanisms of asbestos-induced mesothelioma.
Am. J. Pathol. 134:979-991(1989)

PubMed=9533946; DOI=10.1165/ajrcmb.18.4.2943
Kahlos K., Anttila S., Asikainen T.M., Kinnula K., Raivio K.O., Mattson K., Linnainmaa K., Kinnula V.L.
Manganese superoxide dismutase in healthy human pleural mesothelium and in malignant pleural mesothelioma.
Am. J. Respir. Cell Mol. Biol. 18:570-580(1998)

PubMed=15920167; DOI=10.1016/S0002-9440(10)62492-3; PMCID=PMC1363736
Gordon G.J., Rockwell G.N., Jensen R.V., Rheinwald J.G., Glickman J.N., Aronson J.P., Pottorf B.J., Nitz M.D., Richards W.G., Sugarbaker D.J., Bueno R.
Identification of novel candidate oncogenes and tumor suppressors in malignant pleural mesothelioma using large-scale transcriptional profiling.
Am. J. Pathol. 166:1827-1840(2005)

PubMed=17331233; DOI=10.1186/1471-2164-8-62; PMCID=PMC1821332
Nymark P., Lindholm P.M., Korpela M.V., Lahti L., Ruosaari S., Kaski S., Hollmen J., Anttila S., Kinnula V.L., Knuutila S.
Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines.
BMC Genomics 8:62.1-62.14(2007)

PubMed=21356356; DOI=10.1016/j.ajpath.2010.12.014; PMCID=PMC3070574
Gueugnon F., Leclercq S., Blanquart C., Sagan C., Cellerin L., Padieu M., Perigaud C., Scherpereel A., Gregoire M.
Identification of novel markers for the diagnosis of malignant pleural mesothelioma.
Am. J. Pathol. 178:1033-1042(2011)

PubMed=21454801; DOI=10.1165/rcmb.2010-0282OC; PMCID=PMC3262687
Shukla A., Barrett T.F., MacPherson M.B., Hillegass J.M., Fukagawa N.K., Swain W.A., O'Byrne K.J., Testa J.R., Pass H.I., Faux S.P., Mossman B.T.
An extracellular signal-regulated kinase 2 survival pathway mediates resistance of human mesothelioma cells to asbestos-induced injury.
Am. J. Respir. Cell Mol. Biol. 45:906-914(2011)

PubMed=22576795; DOI=10.3892/or.2012.1763
Ashinuma H., Takiguchi Y., Kitazono S., Kitazono-Saitoh M., Kitamura A., Chiba T., Tada Y., Kurosu K., Sakaida E., Sekine I., Tanabe N., Iwama A., Yokosuka O., Tatsumi K.
Antiproliferative action of metformin in human lung cancer cell lines.
Oncol. Rep. 28:8-14(2012)

PubMed=24926545; DOI=10.1097/JTO.0000000000000202; PMCID=PMC4287384
Riquelme E., Suraokar M.B., Rodriguez J., Mino B., Lin H.Y., Rice D.C., Tsao A., Wistuba I.I.
Frequent coamplification and cooperation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma.
J. Thorac. Oncol. 9:998-1007(2014)

PubMed=26011428; DOI=10.1111/cas.12698; PMCID=PMC4556387
Hakiri S., Osada H., Ishiguro F., Murakami H., Murakami-Tonami Y., Yokoi K., Sekido Y.
Functional differences between wild-type and mutant-type BRCA1-associated protein 1 tumor suppressor against malignant mesothelioma cells.
Cancer Sci. 106:990-999(2015)

PubMed=28553954; DOI=10.1038/onc.2017.147
Kato T., Sato T., Yokoi K., Sekido Y.
E-cadherin expression is correlated with focal adhesion kinase inhibitor resistance in merlin-negative malignant mesothelioma cells.
Oncogene 36:5522-5531(2017)

PubMed=33567673; DOI=10.3390/cancers13040685; PMCID=PMC7915464
Keller M., Reis K., Hjerpe A., Dobra K., Aspenstrom P.
Cytoskeletal organization correlates to motility and invasiveness of malignant mesothelioma cells.
Cancers (Basel) 13:685.1-685.20(2021)

PubMed=34663305; DOI=10.1186/s12935-021-02248-5; PMCID=PMC8525006
Sato T., Nakanishi H., Akao K., Okuda M., Mukai S., Kiyono T., Sekido Y.
Three newly established immortalized mesothelial cell lines exhibit morphological phenotypes corresponding to malignant mesothelioma epithelioid, intermediate, and sarcomatoid types, respectively.
Cancer Cell Int. 21:546.1-546.11(2021)

Cross-references
Cell line collections (Providers) ATCC; CRL-9444
BCRC; 60352
IZSLER; BS CL 214
Cell line databases/resources CLO; CLO_0007680
Biological sample resources BioSample; SAMN03471216
Encyclopedic resources Wikidata; Q54905322
Experimental variables resources EFO; EFO_0001218
Gene expression databases GEO; GSM49613
GEO; GSM139667
GEO; GSM139668
GEO; GSM139669
GEO; GSM139760
GEO; GSM139761
GEO; GSM433109
GEO; GSM433127
GEO; GSM433145
GEO; GSM3684948
Proteomic databases PRIDE; PXD033058
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number25