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Cellosaurus I 2.1 (CVCL_3724)

[Text version]
Cell line name I 2.1
Synonyms I-2-1; I2.1; I2-1
Accession CVCL_3724
Resource Identification Initiative To cite this cell line use: I 2.1 (RRID:CVCL_3724)
Comments Population: Caucasian.
Characteristics: Lacks expression of FADD (PubMed=10616904).
Transformant: ChEBI; CHEBI:132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1061 (Jurkat clone A3)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2572; CCRID=1101HUM-PUMC000241

Markers:
AmelogeninX (CCRID=1101HUM-PUMC000241)
X,Y (ATCC=CRL-2572)
CSF1PO11,12
D2S133819,23
D3S135815,17
D5S8189
D7S8208,10
D8S117912,14
D13S3178,11
D16S53911
D18S5113,21
D19S43313,15.2
D21S1131.2,33.2
FGA19,22
Penta D11
Penta E10,12
TH016,9.3
TPOX8,10
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=10616904
Juo P., Woo M.S.-A., Kuo C.J., Signorelli P., Biemann H.-P., Hannun Y.A., Blenis J.
FADD is required for multiple signaling events downstream of the receptor Fas.
Cell Growth Differ. 10:797-804(1999)

Cross-references
Cell line collections (Providers) ATCC; CRL-2572
Cell line databases/resources CLO; CLO_0004316
cancercelllines; CVCL_3724
CCRID; 1101HUM-PUMC000241
Cell_Model_Passport; SIDM01223
LINCS_LDP; LCL-1027
Biological sample resources BioSample; SAMN03471680
Encyclopedic resources Wikidata; Q54897059
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number26