ID   HKB-11
AC   CVCL_3712
SY   HKB11; Hybrid of Kidney and B cells-11
DR   CLO; CLO_0003772
DR   EFO; EFO_0022587
DR   ATCC; CRL-12568
DR   BioSample; SAMN03473641
DR   FCS-free; 175-2-331-1-4-3
DR   Wikidata; Q27555063
RX   Patent=US6136599;
RX   Patent=US6358703;
RX   PubMed=12432229;
RX   PubMed=25822314;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12568.
CC   Doubling time: 41.0 +- 15.9 hours (Note=In serum-containing medium), 57.6 hours (Note=In FreeStyle medium), 48.1 hours (Note=In CDM4 medium) (PubMed=25822314).
CC   Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5.
CC   Discontinued: ATCC; CRL-12568; true.
ST   Source(s): ATCC=CRL-12568
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11,12
ST   D13S317: 12,14
ST   D16S539: 9,10
ST   D5S818: 8,9,12
ST   D7S820: 10,11,12
ST   TH01: 7,9,9.3
ST   TPOX: 6,11
ST   vWA: 15,16,19
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6354 ! 2B8 [Human Burkitt lymphoma]
HI   CVCL_A784 ! HEK293S
CA   Hybrid cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 24
CH   CVCL_6345 ! 1G2 [Human hybrid]
CH   CVCL_6347 ! 20B8
//
RX   Patent=US6358703;
RA   Cho, Myung-Sam
RA   Chan, Sham-Yuen
RA   Kelsey, William
RA   Yee, Helena
RT   "Expression system for factor VIII.";
RL   Patent number US6358703, 19-Mar-2002.
//
RX   Patent=US6136599;
RA   Cho, Myung-Sam
RT   "Human hybrid host cell for mammalian gene expression.";
RL   Patent number US6136599, 24-Oct-2000.
//
RX   PubMed=25822314; DOI=10.1007/s00449-015-1392-9;
RA   Biaggio, Rafael Tage
RA   de Abreu-Neto, Mario Soares
RA   Covas, Dimas Tadeu
RA   Swiech, Kamilla
RT   "Serum-free suspension culturing of human cells: adaptation, growth,
RT   and cryopreservation.";
RL   Bioprocess Biosyst. Eng. 38:1495-1507(2015).
//
RX   PubMed=12432229; DOI=10.1007/BF02254991;
RA   Cho, Myung-Sam
RA   Yee, Helena
RA   Chan, Sam
RT   "Establishment of a human somatic hybrid cell line for recombinant
RT   protein production.";
RL   J. Biomed. Sci. 9:631-638(2002).
//