ID   HET-1A
AC   CVCL_3702
SY   Het-1A; HET1A; Het1A
DR   BTO; BTO:0004433
DR   CLO; CLO_0003718
DR   ATCC; CRL-2692
DR   BioSample; SAMN03471766
DR   ChEMBL-Cells; CHEMBL4295465
DR   ChEMBL-Targets; CHEMBL4296426
DR   GEO; GSM1375723
DR   GEO; GSM1375724
DR   GEO; GSM1375725
DR   GEO; GSM1375726
DR   GEO; GSM1375735
DR   GEO; GSM1375736
DR   GEO; GSM1375737
DR   GEO; GSM1375738
DR   GEO; GSM1375747
DR   GEO; GSM1375748
DR   GEO; GSM1375749
DR   GEO; GSM1375750
DR   GEO; GSM1508954
DR   GEO; GSM1508958
DR   IARC_TP53; 21630
DR   IARC_TP53; 23555
DR   PubChem_Cell_line; CVCL_3702
DR   Wikidata; Q54882925
RX   CelloPub=CLPUB00265;
RX   DOI=10.1007/978-1-4612-0411-4_30;
RX   DOI=10.1155/2014/376541;
RX   Patent=WO1991005062A1;
RX   PubMed=1703038;
RX   PubMed=7972006;
RX   PubMed=8504475;
RX   PubMed=10078940;
RX   PubMed=20139130;
RX   PubMed=20843300;
RX   PubMed=21127259;
RX   PubMed=28224081;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10209.
CC   Population: African American.
CC   Doubling time: 27.4 +- 3.6 hours (PubMed=21127259).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [Note=pRSV-T].
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Caution: Indicated as originating from a 25 year old male in ATCC, but said to be derived from autopsy specimen from a 74 year old male.
CC   Derived from site: In situ; Esophagus; UBERON=UBERON_0001043.
CC   Cell type: Epithelial cell of esophagus; CL=CL_0002252.
ST   Source(s): ATCC=CRL-2692
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 11
ST   D16S539: 9,11
ST   D18S51: 14
ST   D19S433: 12,14
ST   D21S11: 28,31
ST   D2S1338: 17,23
ST   D3S1358: 15,17
ST   D5S818: 11,12
ST   D7S820: 9
ST   D8S1179: 13,14
ST   FGA: 22,25
ST   Penta D: 12,13
ST   Penta E: 7
ST   TH01: 7
ST   TPOX: 11
ST   vWA: 16
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   74Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 23
//
RX   CelloPub=CLPUB00265;
RA   Stoner G.D., Kaighn M.E., Resau J.H., Naito Z., Bowman D.,
RA   Harris C.C.;
RT   "Immortalized human esophageal epithelial cell lines for studies of
RT   carcinogen-induced cell transformation.";
RL   In Vitro Cell. Dev. Biol. 26:23A-23A(1990).
//
RX   DOI=10.1007/978-1-4612-0411-4_30;
RA   Stoner G.D., Light B.A., Harris C.C.;
RT   "Immortalization and oncogene transformation of human esophageal
RT   epithelial cells.";
RL   (In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.297-305; Humana Press; New York (1990).
//
RX   DOI=10.1155/2014/376541;
RA   Akagi I., Ishibashi O., Matsutani T., Hagiwara N., Matsuda A., Nomura T.,
RA   Makino H., Yoshida H., Miyashita M., Uchida E.;
RT   "Comprehensive analysis of microRNA and mRNA expression in normal and
RT   tumorous human esophageal squamous cell lines using microarray
RT   datasets.";
RL   Dataset Papers Sci. 2013:376541.1-376541.3(2013).
//
RX   Patent=WO1991005062A1;
RA   Stoner G.D., Reddel R.R., Harris C.C.;
RT   "Human esophageal epithelial cell lines.";
RL   Patent number WO1991005062A1, 18-Apr-1991.
//
RX   PubMed=1703038;
RA   Stoner G.D., Kaighn M.E., Reddel R.R., Resau J.H., Bowman D.,
RA   Naito Z., Matsukura N., You M., Galati A.J., Harris C.C.;
RT   "Establishment and characterization of SV40 T-antigen immortalized
RT   human esophageal epithelial cells.";
RL   Cancer Res. 51:365-371(1991).
//
RX   PubMed=7972006; DOI=10.1073/pnas.91.23.11045;
RA   Okamoto A., Demetrick D.J., Spillare E.A., Hagiwara K., Hussain S.P.,
RA   Bennett W.P., Forrester K., Gerwin B.I., Serrano M., Beach D.H.,
RA   Harris C.C.;
RT   "Mutations and altered expression of p16INK4 in human cancer.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994).
//
RX   PubMed=8504475; DOI=10.1093/carcin/14.5.833;
RA   Lehman T.A., Modali R., Boukamp P., Stanek J., Bennett W.P.,
RA   Welsh J.A., Metcalf R.A., Stampfer M.R., Fusenig N.E., Rogan E.M.,
RA   Harris C.C.;
RT   "p53 mutations in human immortalized epithelial cell lines.";
RL   Carcinogenesis 14:833-839(1993).
//
RX   PubMed=10078940; DOI=10.1002/(SICI)1098-2744(199902)24:2<128::AID-MC7>3.0.CO;2-F;
RA   Compton K.R., Orringer M.B., Beer D.G.;
RT   "Induction of glutathione s-transferase-pi in Barrett's metaplasia and
RT   Barrett's adenocarcinoma cell lines.";
RL   Mol. Carcinog. 24:128-136(1999).
//
RX   PubMed=20139130; DOI=10.1093/carcin/bgq036;
RA   Duggan S.P., Behan F.M., Kirca M., Smith S.M., Reynolds J.V., Long A.,
RA   Kelleher D.P.;
RT   "An integrative genomic approach in oesophageal cells identifies TRB3
RT   as a bile acid responsive gene, downregulated in Barrett's oesophagus,
RT   which regulates NF-kappaB activation and cytokine levels.";
RL   Carcinogenesis 31:936-945(2010).
//
RX   PubMed=20843300; DOI=10.1042/BC20100071;
RA   Underwood T.J., Derouet M.F., White M.J., Noble F., Moutasim K.A.,
RA   Smith E., Drew P.A., Thomas G.J., Primrose J.N., Blaydes J.P.;
RT   "A comparison of primary oesophageal squamous epithelial cells with
RT   HET-1A in organotypic culture.";
RL   Biol. Cell 102:635-644(2010).
//
RX   PubMed=21127259; DOI=10.1152/ajpgi.00461.2010;
RA   Goldman A., Chen H.D.R., Roesly H.B., Hill K.A., Tome M.E., Dvorak B.,
RA   Bernstein H., Dvorak K.;
RT   "Characterization of squamous esophageal cells resistant to bile acids
RT   at acidic pH: implication for Barrett's esophagus pathogenesis.";
RL   Am. J. Physiol. Gastrointest. Liver Physiol. 300:G292-G302(2011).
//
RX   PubMed=28224081; DOI=10.1016/j.gdata.2017.02.002;
RA   Akagi I., Ishibashi O.;
RT   "RNA-Seq analysis of human cell lines established from normal and
RT   neoplastic esophageal squamous epithelium.";
RL   Genomics Data 12:4-6(2017).
//