ID   FHC
AC   CVCL_3688
SY   Fetal Human Colon
DR   BTO; BTO_0003808
DR   CLO; CLO_0003236
DR   AddexBio; P0009022/4980
DR   ATCC; CRL-1831
DR   BioSample; SAMN03471253
DR   CCRID; 5301HUM-KCB18026YJ
DR   ChEMBL-Cells; CHEMBL3308603
DR   ChEMBL-Targets; CHEMBL614654
DR   GEO; GSM1448155
DR   IARC_TP53; 28522
DR   KCB; KCB 2017068YJ
DR   KCB; KCB 2018026YJ
DR   PubChem_Cell_line; CVCL_3688
DR   Wikidata; Q54834869
RX   PubMed=6519668;
RX   PubMed=20193843;
CC   Characteristics: Forms solid tumors after transplantation into SCID mice.
CC   Doubling time: ~62 hours (PubMed=6519668).
CC   Karyotypic information: Is hypotriploid, has >20 copies of the 8q23~8q24.3 region containing MYC (PubMed=20193843).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (PubMed=20193843).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Fetal colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
ST   Source(s): AddexBio=P0009022/4980; ATCC=CRL-1831
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 12,13
ST   D16S539: 9,11
ST   D18S51: 15,17
ST   D19S433: 13,14.2
ST   D21S11: 28,29
ST   D2S1338: 17,20
ST   D3S1358: 16,18
ST   D5S818: 12,13
ST   D7S820: 8,12
ST   D8S1179: 14,17
ST   FGA: 21,24.3
ST   Penta D: 9,13
ST   Penta E: 7,14
ST   TH01: 6,9.3
ST   TPOX: 8,11
ST   vWA: 16
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   13FW
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 22
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RX   PubMed=6519668; DOI=10.1007/BF02619632;
RA   Siddiqui K.M., Chopra D.P.;
RT   "Primary and long term epithelial cell cultures from human fetal
RT   normal colonic mucosa.";
RL   In Vitro 20:859-868(1984).
//
RX   PubMed=20193843; DOI=10.1016/j.cancergencyto.2009.11.009;
RA   Soucek K., Gajduskova P., Brazdova M., Hyzd'alova M., Koci L.,
RA   Vydra D., Trojanec R., Pernicova Z., Lentvorska L., Hajduch M.,
RA   Hofmanova J., Kozubik A.;
RT   "Fetal colon cell line FHC exhibits tumorigenic phenotype, complex
RT   karyotype, and TP53 gene mutation.";
RL   Cancer Genet. Cytogenet. 197:107-116(2010).
//