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Cellosaurus T1-73 (CVCL_3605)

[Text version]
Cell line name T1-73
Synonyms TI-73; T173
Accession CVCL_3605
Secondary accession CVCL_1772
Resource Identification Initiative To cite this cell line use: T1-73 (RRID:CVCL_3605)
Comments Problematic cell line: Misclassified. Originally thought to be a osteosarcoma cell line but using a variety of omics methods was shown to be a a fibroblastic cell line (DOI=10.1101/166199; DepMap=ACH-000529).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: Caucasian.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Bone; UBERON=UBERON_0002481.
Cell type: Fibroblast; CL=CL_0000057.
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,01:01
HLA-BB*08:01,44:05
HLA-CC*02:02,07:06
Class II
HLA-DRDRB1*13:86,16:05
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.88
Native American0.25
East Asian, North0.51
East Asian, South0
South Asian3.27
European, North53.75
European, South41.34
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_N340 ! F1-73
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Undefined cell line type
STR profile Source(s): ATCC=CRL-7943

Markers:
AmelogeninX
CSF1PO11
D2S133817,24
D3S135817,19
D5S8188,12
D7S8208,10
D8S117912,14
D13S31711,12
D16S53912
D18S5113,14
D19S43312,15
D21S1130,31.2
FGA19,24
Penta D9,14
Penta E9,12
TH019,9.3
TPOX8,9
vWA15,16

Run an STR similarity search on this cell line
Publications

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

DOI=10.1101/166199
de Weck A., Bitter H., Kauffmann A.
Fibroblasts cell lines misclassified as cancer cell lines.
bioRxiv 2017:166199-166199(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-7943
Cell line databases/resources CLO; CLO_0009241
cancercelllines; CVCL_3605
Cell_Model_Passport; SIDM01765
DepMap; ACH-000529
Biological sample resources BioSample; SAMN03471127
BioSample; SAMN10987677
Chemistry resources ChEMBL-Cells; CHEMBL3308222
ChEMBL-Targets; CHEMBL2366158
GDSC; 910696
PharmacoDB; TI73_1594_2019
PubChem_Cell_line; CVCL_3605
Encyclopedic resources Wikidata; Q54971395
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
GEO; GSM185158
GEO; GSM185159
GEO; GSM827271
GEO; GSM887682
GEO; GSM888774
Polymorphism and mutation databases Cosmic; 687932
Cosmic; 910696
IARC_TP53; 27709
IARC_TP53; 30177
LiGeA; CCLE_417
Progenetix; CVCL_3605
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number28