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Cellosaurus H69AR (CVCL_3513)

[Text version]
Cell line name H69AR
Synonyms H-69AR; NCI-H69AR
Accession CVCL_3513
Resource Identification Initiative To cite this cell line use: H69AR (RRID:CVCL_3513)
Comments Group: Patented cell line.
Part of: MD Anderson Cell Lines Project.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11351.
Population: Caucasian.
Doubling time: ~24 hours (ATCC=CRL-11351).
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1579 (NCI-H69)
Children:
CVCL_4T78 (H69PR)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO10,12
D5S81811,13
D7S8209
D13S31712
D16S53911
TH018,9
TPOX10
vWA16,17

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=2436751
Mirski S.E.L., Gerlach J.H., Cole S.P.C.
Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin.
Cancer Res. 47:2594-2598(1987)

PubMed=1314068; DOI=10.1038/bjc.1992.103
Cole S.P.C., Pinkoski M.J., Bhardwaj G., Deeley R.G.
Elevated expression of annexin II (lipocortin II, p36) in a multidrug resistant small cell lung cancer cell line.
Br. J. Cancer 65:498-502(1992)

Patent=US5489519
Deeley R.G., Cole S.P.C.
Multidrug resistance protein.
Patent number US5489519, 06-Feb-1996

PubMed=17426248; DOI=10.1158/1541-7786.MCR-06-0367
Olejniczak E.T., Van Sant C., Anderson M.G., Wang G., Tahir S.K., Sauter G., Lesniewski R., Semizarov D.
Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.
Mol. Cancer Res. 5:331-339(2007)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections (Providers) ATCC; CRL-11351
Cell line databases/resources CLO; CLO_0003610
cancercelllines; CVCL_3513
IGRhCellID; H69AR
Anatomy/cell type resources BTO; BTO:0005367
Encyclopedic resources Wikidata; Q54872205
Gene expression databases ArrayExpress; E-MTAB-38
GEO; GSM169453
GEO; GSM170728
GEO; GSM827497
GEO; GSM986176
Polymorphism and mutation databases Progenetix; CVCL_3513
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number27