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Cellosaurus Jurkat D1.1 (CVCL_3502)

[Text version]
Cell line name Jurkat D1.1
Synonyms D1.1; D1-1
Accession CVCL_3502
Resource Identification Initiative To cite this cell line use: Jurkat D1.1 (RRID:CVCL_3502)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10915.
Population: Caucasian.
Characteristics: CD4 negative subclone of Jurkat. Induces B cells to express surfac CD 23 molecules, a marker of B cell activation and to proliferate and terminally differentiate into Ig-secreting cells in the presence of T cell dependent B cell mitogens (PubMed=1834738).
Omics: SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0065 (Jurkat)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3600

Markers:
AmelogeninX
CSF1PO11,12
D2S133819,23
D3S135813,15,16,17
D5S8189
D7S8208,10
D8S117912,13
D13S3178,11
D16S53910,11
D18S5112,13,20,21
D19S43313,14.2,15.2
D21S1131.2,32.2,33.2,34.2
FGA19,20,21
Penta D11,13
Penta E10,12
TH016,9.3
TPOX8,10
vWA18,19,20

Run an STR similarity search on this cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=D1.1
Publications

PubMed=1834738; DOI=10.4049/jimmunol.147.10.3389
Yellin M.J., Lee J.J., Chess L., Lederman S.
A human CD4- T cell leukemia subclone with contact-dependent helper function.
J. Immunol. 147:3389-3395(1991)

Patent=US6331433
Lederman S., Chess L., Yellin M.J.
Human T cell leukemia cell line designated D1.1.
Patent number US6331433, 18-Dec-2001

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ATCC; CRL-3600
ATCC; CRL-10915 - Discontinued
Cell line databases/resources CLO; CLO_0002658
cancercelllines; CVCL_3502
Biological sample resources BioSample; SAMN03471307
Encyclopedic resources Wikidata; Q54899131
Gene expression databases GEO; GSM827149
Polymorphism and mutation databases Cosmic; 683659
Progenetix; CVCL_3502
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number28