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Cellosaurus EW-2 (CVCL_3446)

[Text version]
Cell line name EW-2
Synonyms EW2; IARC-EW2; IARC-EW-2; IARC-EW 2
Accession CVCL_3446
Resource Identification Initiative To cite this cell line use: EW-2 (RRID:CVCL_3446)
Comments Population: Caucasian.
Derived from site: Metastatic; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (PubMed=8378080).
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1S20 (GM11222)
Originate from same individual CVCL_1208 ! EW-1
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): PubMed=25010205

Markers:
AmelogeninX,Y
CSF1PO11
D2S133817,23
D3S135817
D5S81815
D7S82011,12
D8S117913
D13S31713,14
D16S53912
D18S5111,12
D19S43313,14
D21S1131.2,32.2
FGA22,26
TH016,9.3
TPOX8,11
vWA19

Run an STR similarity search on this cell line
Publications

PubMed=6713356; DOI=10.1016/0165-4608(84)90002-5
Turc-Carel C., Philip I., Berger M.-P., Philip T., Lenoir G.M.
Chromosome study of Ewing's sarcoma (ES) cell lines. Consistency of a reciprocal translocation t(11;22)(q24;q12).
Cancer Genet. Cytogenet. 12:1-19(1984)

PubMed=8378080
Kovar H., Auinger A., Jug G., Aryee D.N.T., Zoubek A., Salzer-Kuntschik M., Gadner H.
Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours.
Oncogene 8:2683-2690(1993)

PubMed=8108117
Albert T., Urlbauer B., Kohlhuber F., Hammersen B., Eick D.
Ongoing mutations in the N-terminal domain of c-Myc affect transactivation in Burkitt's lymphoma cell lines.
Oncogene 9:759-763(1994)

PubMed=25010205; DOI=10.1371/journal.pgen.1004475; PMCID=PMC4091782
Brohl A.S., Solomon D.A., Chang W., Wang J.-J., Song Y., Sindiri S., Patidar R., Hurd L., Chen L., Shern J.F., Liao H.-L., Wen X.-Y., Gerard J., Kim J.-S., Lopez Guerrero J.A., Machado I., Wai D.H., Picci P., Triche T.J., Horvai A.E., Miettinen M.M., Wei J.S., Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:E1004475-E1004475(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_3446
Cell_Model_Passport; SIDM00204
Encyclopedic resources Wikidata; Q54832998
Polymorphism and mutation databases Cosmic; 1388895
Cosmic; 2228228
Cosmic; 2804870
IARC_TP53; 706
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number16