ID   HCC2185
AC   CVCL_3375
SY   HCC-2185; HCC 2185; Hamon Cancer Center 2185
DR   CLO; CLO_0009909
DR   EFO; EFO_0001178
DR   ArrayExpress; E-TABM-157
DR   ATCC; CRL-2342
DR   BioSample; SAMN03472913
DR   cancercelllines; CVCL_3375
DR   Cosmic; 1136368
DR   DepMap; ACH-002322
DR   GEO; GSM350519
DR   GEO; GSM1053696
DR   GEO; GSM1172964
DR   KCLB; 9S2185
DR   LINCS_HMS; 51093
DR   LINCS_LDP; LCL-2074
DR   PharmacoDB; HCC2185_489_2019
DR   Progenetix; CVCL_3375
DR   Wikidata; Q54881636
RX   PubMed=9833771;
RX   PubMed=11314036;
RX   PubMed=17157791;
RX   PubMed=19582160;
RX   PubMed=20679594;
RX   PubMed=21778573;
RX   PubMed=24094812;
RX   PubMed=24176112;
RX   PubMed=25757734;
RX   PubMed=25877200;
WW   Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
WW   Provider; UT Southwestern; -; https://www.utsouthwestern.edu/edumedia/edufiles/about_us/admin_offices/technology_development/available_technologies/cell-lines.pdf
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: JWGray breast cancer cell line panel.
CC   Characteristics: ER-negative, PR-negative and ERBB2-positive.
CC   Doubling time: 163.56 hours (JWGray panel).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
CC   Miscellaneous: Direct author submission of STR profile from Girard, Luc & Gazdar, Adi F.
CC   Discontinued: ATCC; CRL-2342; true.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): Direct_author_submission; PubMed=20679594; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 8,10
ST   D13S317: 12
ST   D16S539: 10
ST   D18S51: 15
ST   D19S433: 13
ST   D21S11: 32.2
ST   D2S1338: 20
ST   D3S1358: 15,16
ST   D5S818: 11,12
ST   D7S820: 12,13
ST   D8S1179: 14
ST   FGA: 23
ST   Penta D: 11
ST   Penta E: 10
ST   TH01: 9.3
ST   TPOX: 11
ST   vWA: 18,19
DI   NCIt; C76328; Metastatic breast lobular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   49Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 32
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=21778573; DOI=10.3233/BD-2010-0307; PMCID=PMC3532890;
RA   Chavez, Kathryn J.
RA   Garimella, Sireesha Venkata
RA   Lipkowitz, Stanley
RT   "Triple negative breast cancer cell lines: one tool in the search for
RT   better treatment of triple negative breast cancer.";
RL   Breast Dis. 32:35-48(2010).
//
RX   PubMed=20679594; DOI=10.1093/jnci/djq279; PMCID=PMC2935474;
RA   Gazdar, Adi F.
RA   Girard, Luc
RA   Lockwood, William W.
RA   Lam, Wan L.
RA   Minna, John D.
RT   "Lung cancer cell lines as tools for biomedical discovery and
RT   research.";
RL   J. Natl. Cancer Inst. 102:1310-1321(2010).
//
RX   PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590;
RA   Daemen, Anneleen
RA   Griffith, Obi L.
RA   Heiser, Laura M.
RA   Wang, Nicholas J.
RA   Enache, Oana M.
RA   Sanborn, Zachary J.
RA   Pepin, Francois
RA   Durinck, Steffen
RA   Korkola, James E.
RA   Griffith, Malachi
RA   Hur, Joe S.
RA   Huh, Nam
RA   Chung, Jongsuk
RA   Cope, Leslie
RA   Fackler, Mary Jo
RA   Umbricht, Christopher Benedict
RA   Sukumar, Saraswati
RA   Seth, Pankaj
RA   Sukhatme, Vikas P.
RA   Jakkula, Lakshmi R.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Cho, Raymond J.
RA   Collisson, Eric A.
RA   van 't Veer, Laura J.
RA   Spellman, Paul T.
RA   Gray, Joe W.
RT   "Modeling precision treatment of breast cancer.";
RL   Genome Biol. 14:R110.1-R110.14(2013).
//
RX   PubMed=19582160; DOI=10.1371/journal.pone.0006146; PMCID=PMC2702084;
RA   Kao, Jessica
RA   Salari, Keyan
RA   Bocanegra, Melanie
RA   Choi, Yoon-La
RA   Girard, Luc
RA   Gandhi, Jeet
RA   Kwei, Kevin A.
RA   Hernandez-Boussard, Tina
RA   Wang, Pei
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Pollack, Jonathan R.
RT   "Molecular profiling of breast cancer cell lines defines relevant
RT   tumor models and provides a resource for cancer gene discovery.";
RL   PLoS ONE 4:e6146.1-e6146.16(2009).
//
RX   PubMed=9833771; DOI=10.1002/(SICI)1097-0215(19981209)78:6<766::AID-IJC15>3.0.CO;2-L;
RA   Gazdar, Adi F.
RA   Kurvari, Venkatesh
RA   Virmani, Arvind K.
RA   Gollahon, Lauren S.
RA   Sakaguchi, Masahiro
RA   Westerfield, Max
RA   Kodagoda, Dulmini R.
RA   Stasny, Victor
RA   Cunningham, H. Thomas
RA   Wistuba, Ignacio Ivan
RA   Tomlinson, Gail E.
RA   Tonk, Vijay
RA   Ashfaq, Raheela
RA   Leitch, A. Marilyn
RA   Minna, John D.
RA   Shay, Jerry W.
RT   "Characterization of paired tumor and non-tumor cell lines established
RT   from patients with breast cancer.";
RL   Int. J. Cancer 78:766-774(1998).
//
RX   PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008; PMCID=PMC2730521;
RA   Neve, Richard M.
RA   Chin, Koei
RA   Fridlyand, Jane
RA   Yeh, Jennifer
RA   Baehner, Frederick L.
RA   Fevr, Tea
RA   Clark, Laura
RA   Bayani, Nora
RA   Coppe, Jean-Philippe
RA   Tong, Frances
RA   Speed, Terry
RA   Spellman, Paul T.
RA   DeVries, Sandy
RA   Lapuk, Anna
RA   Wang, Nick J.
RA   Kuo, Wen-Lin
RA   Stilwell, Jackie L.
RA   Pinkel, Daniel
RA   Albertson, Donna G.
RA   Waldman, Frederic M.
RA   McCormick, Frank
RA   Dickson, Robert Brent
RA   Johnson, Michael D.
RA   Lippman, Marc E.
RA   Ethier, Stephen P.
RA   Gazdar, Adi F.
RA   Gray, Joe W.
RT   "A collection of breast cancer cell lines for the study of
RT   functionally distinct cancer subtypes.";
RL   Cancer Cell 10:515-527(2006).
//
RX   PubMed=25757734; DOI=10.1186/s13058-015-0517-z; PMCID=PMC4320436;
RA   Christgen, Matthias
RA   Derksen, Patrick W.B.
RT   "Lobular breast cancer: molecular basis, mouse and cellular models.";
RL   Breast Cancer Res. 17:16.1-16.9(2015).
//
RX   PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020; PMCID=PMC3931310;
RA   Timmerman, Luika A.
RA   Holton, Thomas
RA   Yuneva, Mariia
RA   Louie, Raymond J.
RA   Padro, Merce
RA   Daemen, Anneleen
RA   Hu, Min
RA   Chan, Denise A.
RA   Ethier, Stephen P.
RA   van 't Veer, Laura J.
RA   Polyak, Kornelia
RA   McCormick, Frank
RA   Gray, Joe W.
RT   "Glutamine sensitivity analysis identifies the xCT antiporter as a
RT   common triple-negative breast tumor therapeutic target.";
RL   Cancer Cell 24:450-465(2013).
//
RX   PubMed=11314036; DOI=10.1038/sj.onc.1204211;
RA   Forgacs, Eva
RA   Wren, Jonathan D.
RA   Kamibayashi, Craig
RA   Kondo, Masashi
RA   Xu, Xie L.
RA   Markowitz, Sanford David
RA   Tomlinson, Gail E.
RA   Muller, Carolyn Y.
RA   Gazdar, Adi F.
RA   Garner, Harold Ray
RA   Minna, John D.
RT   "Searching for microsatellite mutations in coding regions in lung,
RT   breast, ovarian and colorectal cancers.";
RL   Oncogene 20:1005-1009(2001).
//