ID   Lu-138
AC   CVCL_3350
SY   NCC-c-Lu-138; LU-138
DR   CLO; CLO_0050037
DR   BioSample; SAMN03472077
DR   cancercelllines; CVCL_3350
DR   CGH-DB; 92-1
DR   CGH-DB; 9062-4
DR   Cosmic; 801606
DR   Cosmic; 809122
DR   IARC_TP53; 1016
DR   RCB; RCB1785
DR   Wikidata; Q54903194
RX   PubMed=1312700;
RX   PubMed=3022030;
RX   PubMed=10536175;
RX   PubMed=12107105;
RX   PubMed=38639832;
CC   Population: Chinese.
CC   Doubling time: 72 hours (PubMed=3022030).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Unspecified (PubMed=1312700; PubMed=10536175).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
ST   Source(s): RCB=RCB1785
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 8,11
ST   D16S539: 11
ST   D5S818: 10,12
ST   D7S820: 10,11
ST   TH01: 7,9
ST   TPOX: 8,11
ST   vWA: 17,18
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   78Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 23
//
RX   PubMed=1312700;
RA   Sameshima Y., Matsuno Y., Hirohashi S., Shimosato Y., Mizoguchi H.,
RA   Sugimura T., Terada M., Yokota J.;
RT   "Alterations of the p53 gene are common and critical events for the
RT   maintenance of malignant phenotypes in small-cell lung carcinoma.";
RL   Oncogene 7:451-457(1992).
//
RX   PubMed=3022030; DOI=10.1093/oxfordjournals.jjco.a039144;
RA   Terasaki T., Shimosato Y., Nakajima T., Tsumuraya M., Morinaga S.,
RA   Hirohashi S., Yamaguchi K., Kato K., Ichinose H., Nagatsu T.;
RT   "Changes in cell characteristics due to culture conditions in cell
RT   lines from human small cell lung cancer.";
RL   Jpn. J. Clin. Oncol. 16:203-212(1986).
//
RX   PubMed=10536175; DOI=10.3892/ijo.15.5.927;
RA   Fujita T., Kiyama M., Tomizawa Y., Kohno T., Yokota J.;
RT   "Comprehensive analysis of p53 gene mutation characteristics in lung
RT   carcinoma with special reference to histological subtypes.";
RL   Int. J. Oncol. 15:927-934(1999).
//
RX   PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7; PMCID=PMC1850681;
RA   Yokoi S., Yasui K., Saito-Ohara F., Koshikawa K., Iizasa T.,
RA   Fujisawa T., Terasaki T., Horii A., Takahashi T., Hirohashi S.,
RA   Inazawa J.;
RT   "A novel target gene, SKP2, within the 5p13 amplicon that is
RT   frequently detected in small cell lung cancers.";
RL   Am. J. Pathol. 161:207-216(2002).
//
RX   PubMed=38639832; DOI=10.1007/s13577-024-01055-0; PMCID=PMC11194210;
RA   Kasai F., Fukushima M., Miyagi Y., Nakamura Y.;
RT   "Genetic diversity among the present Japanese population: evidence
RT   from genotyping of human cell lines established in Japan.";
RL   Hum. Cell 37:944-950(2024).
//