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Cellosaurus TYK-nu.CP-r (CVCL_3221)

[Text version]
Cell line name TYK-nu.CP-r
Synonyms TYK-nu (R); TYKNU CPR; TYKnuCPr; TYK-nu-CisR; Tyk-nu-cisR; TYKnuCisR; TyknuCisR
Accession CVCL_3221
Secondary accession CVCL_EQ58
Resource Identification Initiative To cite this cell line use: TYK-nu.CP-r (RRID:CVCL_3221)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Omics: Deep proteome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,26:03
HLA-BB*35:08,58:05
HLA-CC*03:03,07:02
Class II
HLA-DRDRB1*13:07,15:01
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1776 (TYK-nu)
Sex of cell Female
Age at sampling 38Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB0234.1; PubMed=22710073

Markers:
AmelogeninX
CSF1PO12
D2S133818,24
D3S135815
D5S81812,13
D7S82010
D8S117910,15
D13S31710,11
D16S5399,10
D18S5113
D19S43314.2
D21S1132.2
FGA24
TH019
TPOX9,11
vWA14,16

Run an STR similarity search on this cell line
Publications

PubMed=2647872
Yoshiya N., Adachi S., Misawa Y., Yuzawa H., Honda T., Kanazawa K., Takeuchi S., Tanaka K.
Isolation of cisplatin-resistant subline from human ovarian cancer cell line and analysis of its cell-biological characteristics.
Nihon Sanka Fujinka Gakkai Zasshi 41:7-14(1989)

PubMed=11330945; DOI=10.1006/gyno.2001.6132
Watanabe T., Imoto I., Kosugi Y., Ishiwata I., Inoue S., Takayama M., Sato A., Inazawa J.
A novel amplification at 17q21-23 in ovarian cancer cell lines detected by comparative genomic hybridization.
Gynecol. Oncol. 81:172-177(2001)

PubMed=12417041; DOI=10.1111/j.1349-7006.2002.tb01213.x; PMCID=PMC5926887
Watanabe T., Imoto I., Katahira T., Hirasawa A., Ishiwata I., Emi M., Takayama M., Sato A., Inazawa J.
Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers.
Jpn. J. Cancer Res. 93:1114-1122(2002)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27561551; DOI=10.1038/ncomms12645; PMCID=PMC5007461
Coscia F., Watters K.M., Curtis M., Eckert M.A., Chiang C.-Y., Tyanova S., Montag A., Lastra R.R., Lengyel E., Mann M.
Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.
Nat. Commun. 7:12645.1-12645.14(2016)

Cross-references
Cell line collections (Providers) JCRB; JCRB0234.1
Cell line databases/resources cancercelllines; CVCL_3221
CGH-DB; 383-2
CGH-DB; 9360-4
Chemistry resources PharmacoDB; TYKnu_CPr_1615_2019
Encyclopedic resources Wikidata; Q54973462
Experimental variables resources EFO; EFO_0006767
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM851947
Proteomic databases PRIDE; PXD003668
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number26