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Cellosaurus QGP-1 (CVCL_3143)

[Text version]
Cell line name QGP-1
Synonyms QGP 1; QGP1
Accession CVCL_3143
Resource Identification Initiative To cite this cell line use: QGP-1 (RRID:CVCL_3143)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: NCI RAS program mutant KRAS cell line panel.
Population: Japanese.
Doubling time: ~3.5 days (PubMed=7227711); 61 hours (PubMed=25984343); 1.6 +- 0.3 days (PubMed=29330294); 40-50 hours (Note=Lot 04152003), ~2 days (Note=Lot 02162009), ~42 hours (Note=Lot 04112012), ~74 hours (Note=Lot 05312016) (JCRB=JCRB0183).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Misspelling: QGP; CGH-DB=9375-4; GEO=GSM600373.
Misspelling: QCP-1; DOI=10.5772/30884.
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic delta cell; CL=CL_0000173.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Arg2166Gln (c.6497G>A); ClinVar=VCV000230267; Zygosity=Heterozygous (PubMed=25612765; PubMed=29444910; Cosmic-CLP=1298534; DepMap=ACH-000347).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Heterozygous (PubMed=21607521; PubMed=25612765; PubMed=29444910; Cosmic-CLP=1298534; DepMap=ACH-000347).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro98Leufs*25 (c.293delC); Zygosity=Heterozygous (PubMed=25612765; PubMed=29444910; Cosmic-CLP=1298534; DepMap=ACH-000347).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*24:02,24:02
HLA-BB*15:11,67:02
HLA-CC*01:21,12:03
Class II
HLA-DRDRB1*13:26,15:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North82.5
East Asian, South17.02
South Asian0.48
European, North0
European, South0
Disease Pancreatic somatostatinoma (NCIt: C95595)
Somatostatinoma (ORDO: Orphanet_97283)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1298534; JCRB=JCRB0183; PubMed=25877200; PubMed=29444910

Markers:
AmelogeninX
CSF1PO10,12
D3S135814,17
D5S81812
D7S82012
D8S117914
D13S31713
D16S53910,12 (Cosmic-CLP=1298534; JCRB=JCRB0183; PubMed=29444910)
12 (PubMed=25877200)
D18S5113
D21S1129
FGA21,23
Penta D13
Penta E5,24
TH016,9
TPOX8,11
vWA14,17,18 (JCRB=JCRB0183)
14,18 (Cosmic-CLP=1298534; PubMed=25877200; PubMed=29444910)

Run an STR similarity search on this cell line
Web pages https://www.cellosaurus.org/pawefish/PancCellLineDescriptions/QGP-1.html
Publications

PubMed=7227711; DOI=10.20772/cancersci1959.71.5_596
Kaku M., Nishiyama T., Yagawa K., Abe M.
Establishment of a carcinoembryonic antigen-producing cell line from human pancreatic carcinoma.
Gann 71:596-601(1980)

PubMed=6205259; DOI=10.1016/0161-5890(84)90028-2
Kuroki M., Kuroki M., Ichiki S., Matsuoka Y.
Identification and partial characterization of the unglycosylated peptide of carcinoembryonic antigen synthesized by human tumor cell lines in the presence of tunicamycin.
Mol. Immunol. 21:743-746(1984)

PubMed=1971195
Iguchi H., Hayashi I., Kono A.
A somatostatin-secreting cell line established from a human pancreatic islet cell carcinoma (somatostatinoma): release experiment and immunohistochemical study.
Cancer Res. 50:3691-3693(1990)

PubMed=8426738
Kalthoff H., Schmiegel W.H., Roeder C., Kasche D., Schmidt A., Lauer G., Thiele H.-G., Honold G., Pantel K., Riethmuller G., Scherer E., Maurer J., Maacke H., Deppert W.
p53 and K-RAS alterations in pancreatic epithelial cell lesions.
Oncogene 8:289-298(1993)

PubMed=21607521; DOI=10.3892/or.1.6.1223
Iguchi H., Morita R., Yasuda D., Takayanagi R., Ikeda Y., Takada Y., Shimazoe T., Nawata H., Kono A.
Alterations of the p53 tumor-suppressor gene and ki-ras oncogene in human pancreatic cancer-derived cell-lines with different metastatic potential.
Oncol. Rep. 1:1223-1227(1994)

PubMed=11169959; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1049>3.0.CO;2-C
Sirivatanauksorn V., Sirivatanauksorn Y., Gorman P.A., Davidson J.M., Sheer D., Moore P.S., Scarpa A., Edwards P.A.W., Lemoine N.R.
Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping.
Int. J. Cancer 91:350-358(2001)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

DOI=10.5772/30884
Ruckert F., Pilarsky C., Grutzmann R.
Establishment of primary cell lines in pancreatic cancer.
(In book chapter) Pancreatic cancer. Molecular mechanism and targets; Srivastava S. (eds.); pp.259-274; InTechOpen; London; United Kingdom (2012)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22929519; DOI=10.3791/4218; PMCID=PMC3486771
Wong C., Vosburgh E., Levine A.J., Cong L., Xu E.Y.
Human neuroendocrine tumor cell lines as a three-dimensional model for the study of human neuroendocrine tumor therapy.
J. Vis. Exp. 66:e4218.1-e4218.7(2012)

PubMed=23119007; DOI=10.1371/journal.pone.0048411; PMCID=PMC3485222
Li S.-C., Martijn C., Cui T., Essaghir A., Luque R.M., Demoulin J.-B., Castano J.P., Oberg K.E., Giandomenico V.
The somatostatin analogue octreotide inhibits growth of small intestine neuroendocrine tumour cells.
PLoS ONE 7:E48411-E48411(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25612765; DOI=10.1530/JME-14-0304
Vandamme T., Peeters M., Dogan F., Pauwels P., Van Assche E., Beyens M., Mortier G., Vandeweyer G., de Herder W., Van Camp G., Hofland L.J., Op de Beeck K.
Whole-exome characterization of pancreatic neuroendocrine tumor cell lines BON-1 and QGP-1.
J. Mol. Endocrinol. 54:137-147(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26087898; DOI=10.1016/j.cancergen.2015.04.002
Boora G.K., Kanwar R., Kulkarni A.A., Pleticha J., Ames M., Schroth G.P., Beutler A.S., Banck M.S.
Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines.
Cancer Genet. 208:374-381(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29330294; DOI=10.1158/1541-7786.MCR-17-0163
Benten D., Behrang Y., Unrau L., Weissmann V., Wolters-Eisfeld G., Burdak-Rothkamm S., Stahl F.R., Anlauf M., Grabowski P., Mobs M., Dieckhoff J., Sipos B., Fahl M., Eggers C., Perez D., Bockhorn M., Izbicki J.R., Lohse A.W., Schrader J.
Establishment of the first well-differentiated human pancreatic neuroendocrine tumor model.
Mol. Cancer Res. 16:496-507(2018)

PubMed=29444439; DOI=10.1016/j.celrep.2018.01.051; PMCID=PMC6343826
Yuan T.L., Amzallag A., Bagni R., Yi M., Afghani S., Burgan W., Fer N., Strathern L.A., Powell K., Smith B., Waters A.M., Drubin D.A., Thomson T., Liao R., Greninger P., Stein G.T., Murchie E., Cortez E., Egan R.K., Procter L., Bess M., Cheng K.T., Lee C.-S., Lee L.C., Fellmann C., Stephens R., Luo J., Lowe S.W., Benes C.H., McCormick F.
Differential effector engagement by oncogenic KRAS.
Cell Rep. 22:1889-1902(2018)

PubMed=29444910; DOI=10.1530/ERC-17-0445; PMCID=PMC5827037
Hofving T., Arvidsson Y., Almobarak B., Inge L., Pfragner R., Persson M., Stenman G., Kristiansson E., Johanson V., Nilsson O.
The neuroendocrine phenotype, genomic profile and therapeutic sensitivity of GEPNET cell lines.
Endocr. Relat. Cancer 25:367-380(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

CLPUB00598
Behrang Y.
Establishment and characterization of a new human, highly differentiated and functionally active tumor model of a pancreatic neuroendocrine tumor.
Thesis MD (2020); University of Hamburg; Hamburg; Germany

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. 3rd, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=36180704; DOI=10.1007/978-1-0716-2593-4_35
Zibolka J., Bahr I., Peschke E., Muhlbauer E., Bazwinsky-Wutschke I.
Human and rodent cell lines as models of functional melatonin-responsive pancreatic islet cells.
Methods Mol. Biol. 2550:329-352(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB0183
Cell line databases/resources CLO; CLO_0037113
cancercelllines; CVCL_3143
Cell_Model_Passport; SIDM00360
CGH-DB; 9375-4
Cosmic-CLP; 1298534
DepMap; ACH-000347
LINCS_LDP; LCL-1754
Anatomy/cell type resources BTO; BTO:0005500
Biological sample resources BioSample; SAMN03472832
BioSample; SAMN03472892
BioSample; SAMN10988306
Chemistry resources GDSC; 1298534
PharmacoDB; QGP1_1280_2019
Encyclopedic resources Wikidata; Q54948822
Experimental variables resources EFO; EFO_0006741
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM600373
GEO; GSM830112
GEO; GSM827299
GEO; GSM887522
GEO; GSM888604
GEO; GSM1374837
GEO; GSM1670355
Polymorphism and mutation databases Cosmic; 736280
Cosmic; 922260
Cosmic; 933517
Cosmic; 1620106
Cosmic; 1879412
Cosmic; 2433551
Cosmic; 2530677
IARC_TP53; 30149
LiGeA; CCLE_506
Progenetix; CVCL_3143
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number40