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Cellosaurus SRD-12A (CVCL_2H50)

[Text version]
Cell line name SRD-12A
Synonyms Sterol Regulatory Defective-12A
Accession CVCL_2H50
Resource Identification Initiative To cite this cell line use: SRD-12A (RRID:CVCL_2H50)
Comments Characteristics: Has a defect in the site 1 cleavage reaction.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:15455; MBTPS2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCIt; C129643; Cesium-137 gamma radiation.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_2H49 (CHO/pS2P)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=9774448; DOI=10.1074/jbc.273.43.28261
Rawson R.B., Cheng D., Brown M.S., Goldstein J.L.
Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1.
J. Biol. Chem. 273:28261-28269(1998)

Cross-references
Encyclopedic resources Wikidata; Q54955655
Entry history
Entry creation22-Sep-2015
Last entry update19-Dec-2024
Version number10