ID   J-111
AC   CVCL_2965
SY   J 111; J111; JIII; Oregon J-111
DR   CLO; CLO_0006981
DR   CLO; CLO_0007024
DR   CLDB; cl2915
DR   CLDB; cl2916
DR   ATCC; CCL-24
DR   BioSample; SAMN03151724
DR   Cosmic; 919124
DR   Cosmic; 998751
DR   Cosmic; 1037668
DR   ECACC; 93120824
DR   IZSLER; BS TCL 30
DR   IARC_TP53; 21413
DR   JCRB; IFO50005
DR   JCRB; JCRB0073
DR   Wikidata; Q54898403
RX   DOI=10.1007/BF02618370;
RX   PubMed=566722;
RX   PubMed=1246601;
RX   PubMed=4864103;
RX   PubMed=4894370;
RX   PubMed=5641128;
RX   PubMed=6988327;
RX   PubMed=9290701;
RX   PubMed=9510473;
RX   PubMed=11416159;
RX   PubMed=12592342;
RX   PubMed=13260360;
RX   PubMed=13431913;
RX   PubMed=14185313;
RX   PubMed=20143388;
RX   PubMed=21246756;
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Group: Space-flown cell line (cellonaut).
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=4864103; PubMed=5641128; PubMed=566722; PubMed=1246601; PubMed=12592342; PubMed=20143388). Originally thought to originate from a 25 year old female patient with acute monocytic leukemia.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00009.
CC   Population: African American.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Anecdotal: Have been flown in space on the ISS to study motility and cytoskeletal structures (PubMed=21246756).
CC   Miscellaneous: Formerly the CCRID database had an entry describing this cell line (3111C0002000000054). It was one of the sources for the STR profile of this entry.
CC   Discontinued: ATCC; CCL-24; true.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): CCRID; JCRB; PubMed=11416159
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D13S317: 12,13.3 (JCRB)
ST   D13S317: 12,14 (CCRID)
ST   D16S539: 9,10
ST   D18S51: 16
ST   D21S11: 27,28
ST   D3S1358: 15,18
ST   D5S818: 11,12
ST   D7S820: 8,12
ST   D8S1179: 12
ST   FGA: 18,21
ST   Penta D: 8,15
ST   Penta E: 7,17
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 16,18
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 28
//
RX   DOI=10.1007/BF02618370;
RA   Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.;
RT   "The animal cell culture collection.";
RL   In Vitro 5:1-16(1970).
//
RX   PubMed=566722; DOI=10.1007/BF02616110;
RA   Lavappa K.S.;
RT   "Survey of ATCC stocks of human cell lines for HeLa contamination.";
RL   In Vitro 14:469-475(1978).
//
RX   PubMed=1246601; DOI=10.1126/science.1246601;
RA   Nelson-Rees W.A., Flandermeyer R.R.;
RT   "HeLa cultures defined.";
RL   Science 191:96-98(1976).
//
RX   PubMed=4864103;
RA   Gartler S.M.;
RT   "Genetic markers as tracers in cell culture.";
RL   Natl. Cancer Inst. Monogr. 26:167-195(1967).
//
RX   PubMed=4894370; DOI=10.1002/1097-0142(196908)24:2<211::AID-CNCR2820240202>3.0.CO;2-3;
RA   Southam C.M., Burchenal J.H., Clarkson B.D. Sr., Tanzi A., Mackey R.,
RA   McComb V.;
RT   "Heterotransplantability of human cell lines derived from leukemia and
RT   lymphomas into immunologically tolerant rats.";
RL   Cancer 24:211-222(1969).
//
RX   PubMed=5641128; DOI=10.1038/217750a0;
RA   Gartler S.M.;
RT   "Apparent Hela cell contamination of human heteroploid cell lines.";
RL   Nature 217:750-751(1968).
//
RX   PubMed=6988327; DOI=10.1007/BF02831503;
RA   O'Brien S.J., Shannon J.E., Gail M.H.;
RT   "A molecular approach to the identification and individualization of
RT   human and animal cells in culture: isozyme and allozyme genetic
RT   signatures.";
RL   In Vitro 16:119-135(1980).
//
RX   PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D;
RA   Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T.,
RA   Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M.,
RA   Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.;
RT   "Screening the p53 status of human cell lines using a yeast functional
RT   assay.";
RL   Mol. Carcinog. 19:243-253(1997).
//
RX   PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x;
RA   Hosoya N., Hangaishi A., Ogawa S., Miyagawa K., Mitani K., Yazaki Y.,
RA   Hirai H.;
RT   "Frameshift mutations of the hMSH6 gene in human leukemia cell
RT   lines.";
RL   Jpn. J. Cancer Res. 89:33-39(1998).
//
RX   PubMed=11416159; DOI=10.1073/pnas.121616198;
RA   Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G.,
RA   Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R.,
RA   Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.;
RT   "Short tandem repeat profiling provides an international reference
RT   standard for human cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
//
RX   PubMed=12592342; DOI=10.1038/sj.leu.2402799;
RA   Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.;
RT   "False leukemia-lymphoma cell lines: an update on over 500 cell
RT   lines.";
RL   Leukemia 17:416-426(2003).
//
RX   PubMed=13260360; DOI=10.1182/blood.V10.10.1010.1010;
RA   Osgood E.E., Brooke J.H.;
RT   "Continuous tissue culture of leukocytes from human leukemic bloods by
RT   application of gradient principles.";
RL   Blood 10:1010-1022(1955).
//
RX   PubMed=13431913; DOI=10.3181/00379727-94-23044;
RA   Foley G.E., Handler A.H.;
RT   "Differentiation of normal and neoplastic cells maintained in tissue
RT   culture by implantation into normal hamsters.";
RL   Proc. Soc. Exp. Biol. Med. 94:661-664(1957).
//
RX   PubMed=14185313; DOI=10.1126/science.146.3641.241;
RG   Cell Culture Collection Committee;
RT   "Animal cell strains. The Cell Culture Collection Committee has
RT   assembled and certified 23 strains of animal cells.";
RL   Science 146:241-243(1964).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=21246756; DOI=10.1002/cm.20499;
RA   Meloni M.A., Galleri G., Pani G., Saba A., Pippia P.,
RA   Cogoli-Greuter M.;
RT   "Space flight affects motility and cytoskeletal structures in human
RT   monocyte cell line J-111.";
RL   Cytoskeleton 68:125-137(2011).
//