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Cellosaurus CPT-K5 (CVCL_2878)

[Text version]
Cell line name CPT-K5
Synonyms CPT-K-5; CPTK5; RPMI 8402/CPTK5
Accession CVCL_2878
Resource Identification Initiative To cite this cell line use: CPT-K5 (RRID:CVCL_2878)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_80630; Irinotecan (Camptothecin-11; CPT-11).
Omics: Array-based CGH.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:10879; STIL + HGNC; HGNC:11556; TAL1; Name(s)=STIL-TAL1, SIL-TAL1, SIL-SCL (PubMed=29496689).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465His (c.1394G>A); ClinVar=VCV000376415; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Glu1583_Gln1584insProValGluLeuMetProProGlu (c.4750_4751insCCGTGGAGCTGATGCCGCCGGAGC); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg159Ser (c.477G>T); ClinVar=VCV000375959; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11986; TOP1; Simple; p.Asp533Gly (c.1598A>G); ClinVar=VCV000016773; Zygosity=Unspecified (PubMed=1849260).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:12796; WT1; Simple; p.Ser121Ter (c.362C>A); Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1667 (RPMI-8402)
Sex of cell Female
Age at sampling 16Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1067; PubMed=29496689

Markers:
AmelogeninX
CSF1PO9,10,11,12
D2S133823,24,26,27
D3S135814,15,16
D5S81811,12,13
D7S8209,12,14
D8S117913,14
D13S31710,12
D16S53910,14
D18S5114,17,18
D19S43314,15
D21S1128,30,33.2,34.2
FGA21,22,24
TH016,7
TPOX8
vWA17,18,20,22

Run an STR similarity search on this cell line
Publications

PubMed=3039492; DOI=10.1073/pnas.84.16.5565; PMCID=PMC298903
Andoh T., Ishii K., Suzuki Y., Ikegami Y., Kusunoki Y., Takemoto Y., Okada K.
Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.
Proc. Natl. Acad. Sci. U.S.A. 84:5565-5569(1987)

PubMed=1849260; DOI=10.1093/nar/19.1.69; PMCID=PMC333535
Tamura H.-o., Kohchi C., Yamada R., Ikeda T., Koiwai O., Patterson E., Keene J.D., Okada K., Kjeldsen E., Nishikawa K., Andoh T.
Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites.
Nucleic Acids Res. 19:69-75(1991)

PubMed=14679002
Li T.-K., Houghton P.J., Desai S.D., Daroui P., Liu A.A., Hars E.S., Ruchelman A.L., LaVoie E.J., Liu L.F.
Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.
Cancer Res. 63:8400-8407(2003)

PubMed=29496689; DOI=10.21873/cgp.20068; PMCID=PMC5892604
Kjeldsen E., Nielsen C.J.F., Roy A., Tesauro C., Jakobsen A.-K., Stougaard M., Knudsen B.R.
Characterization of camptothecin-induced genomic changes in the camptothecin-resistant T-ALL-derived cell line CPT-K5.
Cancer Genomics Proteomics 15:91-114(2018)

Cross-references
Cell line collections (Providers) JCRB; JCRB1067
Cell line databases/resources cancercelllines; CVCL_2878
Biological sample resources BioSample; SAMN03472497
Encyclopedic resources Wikidata; Q54814409
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number24