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Cellosaurus UM-UC-5 (CVCL_2750)

[Text version]
Cell line name UM-UC-5
Synonyms UMUC5; University of Michigan-Urothelial Carcinoma-5
Accession CVCL_2750
Resource Identification Initiative To cite this cell line use: UM-UC-5 (RRID:CVCL_2750)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: UBC-40 urothelial bladder cancer cell line index.
Doubling time: 19 hours (PubMed=3761468).
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Trp53Ter (c.159G>A); ClinVar=VCV000420659; Zygosity=Unspecified (DepMap=ACH-001411).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001411; ECACC=08090502

Markers:
AmelogeninX
CSF1PO11
D3S135815
D5S81813
D7S82010,12
D8S117912,13
D13S3178,12
D16S53911,13
D18S5113,16
D21S1132.2
FGA20
Penta D9
Penta E15,17
TH017,9
TPOX9,11
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=3761468; DOI=10.1016/S0022-5347(17)45139-1
Grossman H.B., Wedemeyer G., Ren L.-Q., Wilson G.N., Cox B.
Improved growth of human urothelial carcinoma cell cultures.
J. Urol. 136:953-959(1986)

PubMed=24018021; DOI=10.1016/j.eururo.2013.08.052
Allory Y., Beukers W., Sagrera A., Flandez M., Marques M., Marquez M., van der Keur K.A., Dyrskjot L., Lurkin I., Vermeij M., Carrato A., Lloreta J., Lorente J.A., Carrillo-de-Santa-Pau E., Masius R.G., Kogevinas M., Steyerberg E.W., van Tilborg A.A.G., Abas C., Orntoft T.F., Zuiverloon T.C.M., Malats N., Zwarthoff E.C., Real F.X.
Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.
Eur. Urol. 65:360-366(2014)

PubMed=25997541; DOI=10.1186/s12864-015-1450-3; PMCID=PMC4470036
Earl J., Rico D., Carrillo-de-Santa-Pau E., Rodriguez-Santiago B., Mendez-Pertuz M., Auer H., Gomez G., Grossman H.B., Pisano D.G., Schulz W.A., Perez-Jurado L.A., Carrato A., Theodorescu D., Chanock S.J., Valencia A., Real F.X.
The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
BMC Genomics 16:403.1-403.16(2015)

PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

Cross-references
Cell line collections (Providers) CancerTools; 160437
ECACC; 08090502
Cell line databases/resources cancercelllines; CVCL_2750
Cell_Model_Passport; SIDM01909
DepMap; ACH-001411
Anatomy/cell type resources BTO; BTO_0004993
Encyclopedic resources Wikidata; Q54990992
Gene expression databases GEO; GSM1567863
GEO; GSM1574558
Polymorphism and mutation databases Cosmic; 1082648
Cosmic; 1938702
Cosmic; 2037969
Cosmic; 2700983
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number28