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Cellosaurus SIRC (CVCL_2724)

[Text version]
Cell line name SIRC
Synonyms Sirc; Statens Seruminstitut Rabbit Cornea
Accession CVCL_2724
Resource Identification Initiative To cite this cell line use: SIRC (RRID:CVCL_2724)
Comments Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Characteristics: Expresses a mix of epithelial and fibroblastic markers (PubMed=29653143).
Virology: Can be used for isolation and growth of rubella virus.
Virology: Not susceptible to infection by bovine viral diarrhea virus (BVDV) (PubMed=7989438).
Doubling time: ~31 hours (Note=Lot 11132012), ~1.5 days (Note=Lot 10272017) (JCRB=JCRB9122).
Derived from site: In situ; Eye, cornea; UBERON=UBERON_0000964.
Species of origin Oryctolagus cuniculus (Rabbit) (NCBI Taxonomy: 9986)
Hierarchy Children:
CVCL_E3FC (SIRC-CD4)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Spontaneously immortalized cell line
Publications

PubMed=14331182; DOI=10.1126/science.149.3684.633
Leerhoy J.
Cytopathic effect of rubella virus in a rabbit-cornea cell line.
Science 149:633-634(1965)

PubMed=5918951; DOI=10.3181/00379727-122-31251
Phillips C.A., Melnick J.L., Burkhardt M.
Isolation, propagation and neutralization of rubella virus in cultures of rabbit cornea (SIRC) cells.
Proc. Soc. Exp. Biol. Med. 122:783-786(1966)

DOI=10.1007/BF02618370
Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.
The animal cell culture collection.
In Vitro 5:1-16(1970)

PubMed=6500159; DOI=10.1159/000163283
Gershwin M.E., Lentz D., Owens R.B.
Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.
Exp. Cell Biol. 52:361-370(1984)

PubMed=2228906; DOI=10.1007/BF02624618
Niederkorn J.Y., Meyer D.R., Ubelaker J.E., Martin J.H.
Ultrastructural and immunohistological characterization of the SIRC corneal cell line.
In Vitro Cell. Dev. Biol. 26:923-930(1990)

PubMed=7989438; DOI=10.1016/0166-0934(94)90120-1
Bolin S.R., Ridpath J.F., Black J.W., Macy M.L., Roblin R.O. 3rd
Survey of cell lines in the American Type Culture Collection for bovine viral diarrhea virus.
J. Virol. Methods 48:211-221(1994)

PubMed=29653143; DOI=10.1016/j.exer.2018.04.004
Olivieri M., Cristaldi M., Pezzino S., Rusciano D., Tomasello B., Anfuso C.D., Lupo G.
Phenotypic characterization of the SIRC (Statens Seruminstitut Rabbit Cornea) cell line reveals a mixed epithelial and fibroblastic nature.
Exp. Eye Res. 172:123-127(2018)

PubMed=34737324; DOI=10.1038/s41598-021-00779-5; PMCID=PMC8569163
Lung O., Candlish R.C., Nebroski M., Kruckiewicz P., Buchanan C., Moniwa M.
High-throughput sequencing for species authentication and contamination detection of 63 cell lines.
Sci. Rep. 11:21657-21657(2021)

Cross-references
Cell line collections (Providers) ATCC; CCL-60
ATCC; CRL-6595 - Discontinued
BCRC; 60093
BCRJ; 0224
ECACC; 89090404
ICLC; AL96001
IZSLER; BS CL 79
JCRB; IFO50020
JCRB; JCRB9122
RCB; RCB1835
Cell line databases/resources CLO; CLO_0009019
CLO; CLO_0009020
CLO; CLO_0050407
CLDB; cl4301
CLDB; cl4302
CLDB; cl4304
CLDB; cl4305
CLDB; cl4306
CLDB; cl4307
Lonza; 1197
TOKU-E; 3120
Anatomy/cell type resources BTO; BTO_0004495
Encyclopedic resources Wikidata; Q54953505
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number26