ID   RB247C
AC   CVCL_2704
SY   RB247c; RB247; RB 247; Rb247; RB247C-3; RB247C3; RB247c3
DR   ECACC; 06070601
DR   GEO; GSM2043878
DR   Wikidata; Q54949297
RX   PubMed=1682862;
RX   PubMed=2090524;
RX   PubMed=2365495;
RX   PubMed=2751270;
RX   PubMed=11520568;
RX   PubMed=15326157;
RX   PubMed=18036396;
RX   PubMed=23498719;
RX   PubMed=27115612;
RX   PubMed=30584916;
RX   PubMed=32123578;
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Pro39Argfs*26 (c.116delC); Zygosity=Heterozygous (PubMed=30584916).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Gly617Argfs*36 (c.1848dup); Zygosity=Heterozygous (PubMed=30584916).
CC   Omics: Transcriptome analysis by microarray.
DI   NCIt; C8713; Bilateral retinoblastoma
DI   ORDO; Orphanet_790; Retinoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 14
//
RX   PubMed=1682862; DOI=10.1016/S0161-6420(91)32134-1;
RA   Chan H.S.L., Thorner P.S., Haddad G., Gallie B.L.;
RT   "Multidrug-resistant phenotype in retinoblastoma correlates with
RT   P-glycoprotein expression.";
RL   Ophthalmology 98:1425-1431(1991).
//
RX   PubMed=2090524; DOI=10.1111/j.1432-0436.1990.tb00479.x;
RA   Griegel S., Heise K., Kindler-Rohrborn A., Rajewsky M.F.;
RT   "In vitro differentiation of human retinoblastoma cells into neuronal
RT   phenotypes.";
RL   Differentiation 45:250-257(1990).
//
RX   PubMed=2365495; DOI=10.1002/ijc.2910460123;
RA   Griegel S., Hong C., Frotschl R., Hulser D.F., Greger V.,
RA   Horsthemke B., Rajewsky M.F.;
RT   "Newly established human retinoblastoma cell lines exhibit an
RT   'immortalized' but not an invasive phenotype in vitro.";
RL   Int. J. Cancer 46:125-132(1990).
//
RX   PubMed=2751270;
RA   Chan H.S.L., Canton M.D., Gallie B.L.;
RT   "Chemosensitivity and multidrug resistance to antineoplastic drugs in
RT   retinoblastoma cell lines.";
RL   Anticancer Res. 9:469-474(1989).
//
RX   PubMed=11520568; DOI=10.1016/S0165-4608(01)00427-7;
RA   Chen D., Gallie B.L., Squire J.A.;
RT   "Minimal regions of chromosomal imbalance in retinoblastoma detected
RT   by comparative genomic hybridization.";
RL   Cancer Genet. Cytogenet. 129:57-63(2001).
//
RX   PubMed=15326157; DOI=10.1167/iovs.04-0140;
RA   DiCiommo D.P., Duckett A., Burcescu I., Bremner R., Gallie B.L.;
RT   "Retinoblastoma protein purification and transduction of retina and
RT   retinoblastoma cells using improved alphavirus vectors.";
RL   Invest. Ophthalmol. Vis. Sci. 45:3320-3329(2004).
//
RX   PubMed=18036396; DOI=10.1016/j.cancergencyto.2007.08.014;
RA   Paderova J., Orlic-Milacic M., Yoshimoto M., da Cunha Santos G.,
RA   Gallie B.L., Squire J.A.;
RT   "Novel 6p rearrangements and recurrent translocation breakpoints in
RT   retinoblastoma cell lines identified by spectral karyotyping and mBAND
RT   analyses.";
RL   Cancer Genet. Cytogenet. 179:102-111(2007).
//
RX   PubMed=23498719; DOI=10.1016/S1470-2045(13)70045-7;
RA   Rushlow D.E., Mol B.M., Kennett J.Y., Yee S., Pajovic S.,
RA   Theriault B.L., Prigoda-Lee N.L., Spencer C., Dimaras H., Corson T.W.,
RA   Pang R., Massey C., Godbout R., Jiang Z., Zacksenhaus E., Paton K.,
RA   Moll A.C., Houdayer C., Raizis A., Halliday W., Lam W.L.,
RA   Boutros P.C., Lohmann D.R., Dorsman J.C., Gallie B.L.;
RT   "Characterisation of retinoblastomas without RB1 mutations: genomic,
RT   gene expression, and clinical studies.";
RL   Lancet Oncol. 14:327-334(2013).
//
RX   PubMed=27115612; DOI=10.1371/journal.pone.0153323; PMCID=PMC4846005;
RA   Kooi I.E., Mol B.M., Massink M.P.G., de Jong M.C., de Graaf P.,
RA   van der Valk P., Meijers-Heijboer H., Kaspers G.J.L., Moll A.C.,
RA   te Riele H., Cloos J., Dorsman J.C.;
RT   "A meta-analysis of retinoblastoma copy numbers refines the list of
RT   possible driver genes involved in tumor progression.";
RL   PLoS ONE 11:E0153323-E0153323(2016).
//
RX   PubMed=30584916; DOI=10.1016/j.yexcr.2018.12.018;
RA   Schwermer M., Hiber M., Dreesmann S., Rieb A., Theissen J., Herold T.,
RA   Schramm A., Temming P., Steenpass L.;
RT   "Comprehensive characterization of RB1 mutant and MYCN amplified
RT   retinoblastoma cell lines.";
RL   Exp. Cell Res. 375:92-99(2019).
//
RX   PubMed=32123578; DOI=10.1038/s41420-020-0237-8; PMCID=PMC7026052;
RA   Aubry A., Yu T., Bremner R.;
RT   "Preclinical studies reveal MLN4924 is a promising new retinoblastoma
RT   therapy.";
RL   Cell Death Discov. 6:2.1-2.12(2020).
//