Cellosaurus logo
expasy logo

Cellosaurus PEO23 (CVCL_2689)

[Text version]
Cell line name PEO23
Synonyms PE023
Accession CVCL_2689
Resource Identification Initiative To cite this cell line use: PEO23 (RRID:CVCL_2689)
Comments Part of: OCCP ovarian cancer cell line panel.
Doubling time: 120 hours (PubMed=3167863).
Omics: Deep proteome analysis.
Omics: Genome sequenced.
Omics: SNP array analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
HLA typing Source: PubMed=25960936
Class I
HLA-AA*11:01,11:01
HLA-BB*35:01,35:01
HLA-CC*04:01,04:01
Class II
HLA-DQDQB1*05:01,05:01
HLA-DRDRB1*01:01,01:01
Disease Ovarian cystadenocarcinoma (NCIt: C5228)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2687 ! PEO14
CVCL_2734 ! TO14
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ECACC=10032313; PubMed=22183581; PubMed=25230021

Markers:
AmelogeninX
CSF1PO11
D2S133824
D3S135816
D5S81811,12 (ECACC=10032313)
12 (PubMed=22183581; PubMed=25230021)
D7S8209,10
D8S117913,14
D13S31711,12
D16S53911
D18S5115
D19S43314,15
D21S1127,30
FGA20
Penta D9,13
Penta E10
TH016
TPOX8,11
vWA15,16

Run an STR similarity search on this cell line
Publications

PubMed=3167863
Langdon S.P., Lawrie S.S., Hay F.G., Hawkes M.M., McDonald A., Hayward I.P., Schol D.J., Hilgers J., Leonard R.C.F., Smyth J.F.
Characterization and properties of nine human ovarian adenocarcinoma cell lines.
Cancer Res. 48:6166-6172(1988)

PubMed=20581869; DOI=10.1038/onc.2010.245; PMCID=PMC2933510
Cooke S.L., Ng C.K.Y., Melnyk N., Garcia M.J., Hardcastle T.J., Temple J., Langdon S.P., Huntsman D.G., Brenton J.D.
Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma.
Oncogene 29:4905-4913(2010)

PubMed=22183581; DOI=10.1002/path.3980
Ng C.K.Y., Cooke S.L., Howe K.L., Newman S., Xian J., Temple J., Batty E.M., Pole J.C.M., Langdon S.P., Edwards P.A.W., Brenton J.D.
The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer.
J. Pathol. 226:703-712(2012)

PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023
Stordal B., Timms K., Farrelly A., Gallagher D., Busschots S., Renaud M., Thery J., Williams D., Potter J., Tran T., Korpanty G., Cremona M., Carey M.S., Li J., Li Y., Aslan O., O'Leary J.J., Mills G.B., Hennessy B.T.
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
Mol. Oncol. 7:567-579(2013)

PubMed=25230021; DOI=10.1371/journal.pone.0103988; PMCID=PMC4167545
Beaufort C.M., Helmijr J.C.A., Piskorz A.M., Hoogstraat M., Ruigrok-Ritstier K., Besselink N., Murtaza M., van IJcken W.F.J., Heine A.A.J., Smid M., Koudijs M.J., Brenton J.D., Berns E.M.J.J., Helleman J.
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS ONE 9:E103988-E103988(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=28273451; DOI=10.1016/j.celrep.2017.02.028
Medrano M., Communal L., Brown K.R., Iwanicki M., Normand J., Paterson J., Sircoulomb F., Krzyzanowski P.M., Novak M., Doodnauth S.A., Suarez Saiz F.J., Cullis J., Al-awar R., Neel B.G., McPherson J., Drapkin R.I., Ailles L., Mes-Masson A.-M., Rottapel R.
Interrogation of functional cell-surface markers identifies CD151 dependency in high-grade serous ovarian cancer.
Cell Rep. 18:2343-2358(2017)

PubMed=35028612; DOI=10.1016/j.xcrm.2021.100471; PMCID=PMC8714940
Huang D.-Q., Chowdhury S., Wang H., Savage S.R., Ivey R.G., Kennedy J.J., Whiteaker J.R., Lin C.-W., Hou X.-N., Oberg A.L., Larson M.C., Eskandari N., Delisi D.A., Gentile S., Huntoon C.J., Voytovich U.J., Shire Z.J., Yu Q., Gygi S.P., Hoofnagle A.N., Herbert Z.T., Lorentzen T.D., Calinawan A., Karnitz L.M., Weroha S.J., Kaufmann S.H., Zhang B., Wang P., Birrer M.J., Paulovich A.G.
Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer.
Cell Rep. Med. 2:100471.1-100471.32(2021)

Cross-references
Cell line collections (Providers) CancerTools; 151677
ECACC; 10032313 - Discontinued
Ximbio; 151677
Cell line databases/resources cancercelllines; CVCL_2689
Cell_Model_Passport; SIDM01418
Encyclopedic resources Wikidata; Q54947167
Experimental variables resources EFO; EFO_0005447
Gene expression databases ArrayExpress; E-MTAB-691
GEO; GSM459857
GEO; GSM2475001
GEO; GSM4973224
GEO; GSM4973230
GEO; GSM4973236
GEO; GSM4973242
GEO; GSM4973254
GEO; GSM4973266
GEO; GSM4973248
GEO; GSM4973260
GEO; GSM4973272
Polymorphism and mutation databases Progenetix; CVCL_2689
Proteomic databases PRIDE; PXD020764
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number26