ID   OKT 3
AC   CVCL_2665
SY   OKT3
DR   CLO; CLO_0008252
DR   CLDB; cl5239
DR   ABCD; ABCD_AC852
DR   ATCC; CRL-8001
DR   BCRC; 60154
DR   CCRID; 3101ETCHYB58
DR   CLS; 300499
DR   ECACC; 86022706
DR   IZSLER; BS Hy 12
DR   NCBI_Iran; H104
DR   TKG; TKG 0235
DR   Wikidata; Q54931950
RX   DOI=10.1007/978-1-4899-1236-7_4;
RX   Patent=US4361549;
RX   PubMed=314668;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8001.
CC   Biotechnology: The monoclonal antibody produced by this hybridoma was used as an immunosuppressant drug under the name Muromonab-CD3 (Orthoclone OKT3).
CC   Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized teplizumab (MGA031) therapeutic antibody.
CC   Monoclonal antibody isotype: IgG2a.
CC   Monoclonal antibody target: UniProtKB; P07766; Human CD3E.
CC   Anecdotal: OKT3 was the first monoclonal antibody to be approved for clinical use in humans.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_3412 ! P3X63Ag8U.1
CA   Hybridoma
DT   Created: 04-04-12; Last updated: 21-03-23; Version: 14
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RX   DOI=10.1007/978-1-4899-1236-7_4;
RA   Rao P.E., Kroon D.J.;
RT   "Orthoclone OKT3.";
RL   (In) Stability and characterization of protein and peptide drugs. Pharmaceutical Biotechnology, Vol. 5; Wang Y.J., Pearlman R. (eds.); pp.135-158; Springer; Boston (1993).
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RX   Patent=US4361549;
RA   Kung P.C., Goldstein G.;
RT   "Complement-fixing monoclonal antibody to human T cells, and methods
RT   of preparing same.";
RL   Patent number US4361549, 30-Nov-1982.
//
RX   PubMed=314668; DOI=10.1126/science.314668;
RA   Kung P.C., Goldstein G., Reinherz E.L., Schlossman S.F.;
RT   "Monoclonal antibodies defining distinctive human T cell surface
RT   antigens.";
RL   Science 206:347-349(1979).
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