ID   NO36
AC   CVCL_2658
DR   BioSample; SAMN07624411
DR   cancercelllines; CVCL_2658
DR   CBA; CBA-0142
DR   Cosmic; 1522764
DR   Cosmic; 1963331
DR   DepMap; ACH-001977
DR   ECACC; 10092312
DR   GEO; GSM796439
DR   Progenetix; CVCL_2658
DR   Wikidata; Q54930861
RX   PubMed=1703129;
RX   PubMed=21642991;
RX   PubMed=25902174;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Sequence variation: Mutation; HGNC; 950; BAP1; Simple; p.Phe118Leufs*69 (c.354delC); Zygosity=Heterozygous (PubMed=21642991; DepMap=ACH-001977).
CC   Transformant: ChEBI; CHEBI:46666; Crocidolite asbestos.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): CBA=CBA-0142
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 8
ST   D16S539: 11,13
ST   D18S51: 21,22
ST   D19S433: 15,16
ST   D21S11: 28,29
ST   D2S1338: 25
ST   D3S1358: 15,16
ST   D5S818: 12,13
ST   D7S820: 11
ST   D8S1179: 12
ST   FGA: 22
ST   TH01: 6,7
ST   TPOX: 8,11
ST   vWA: 16,18
DI   NCIt; C45662; Pleural epithelioid mesothelioma
DI   ORDO; Orphanet_50251; Pleural mesothelioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   36-62Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 21
//
RX   PubMed=1703129; DOI=10.1002/ijc.2910470219;
RA   Manning L.S., Whitaker D., Murch A.R., Garlepp M.J., Davis M.R.,
RA   Musk A.W., Robinson B.W.S.;
RT   "Establishment and characterization of five human malignant
RT   mesothelioma cell lines derived from pleural effusions.";
RL   Int. J. Cancer 47:285-290(1991).
//
RX   PubMed=21642991; DOI=10.1038/ng.855; PMCID=PMC4643098;
RA   Bott M.J., Brevet M., Taylor B.S., Shimizu S., Ito T., Wang L.,
RA   Creaney J., Lake R.A., Zakowski M.F., Reva B., Sander C., Delsite R.,
RA   Powell S.N., Zhou Q., Shen R.-L., Olshen A.B., Rusch V.W., Ladanyi M.;
RT   "The nuclear deubiquitinase BAP1 is commonly inactivated by somatic
RT   mutations and 3p21.1 losses in malignant pleural mesothelioma.";
RL   Nat. Genet. 43:668-672(2011).
//
RX   PubMed=25902174; DOI=10.1097/JTO.0000000000000493;
RA   Miyanaga A., Masuda M., Tsuta K., Kawasaki K., Nakamura Y., Sakuma T.,
RA   Asamura H., Gemma A., Yamada T.;
RT   "Hippo pathway gene mutations in malignant mesothelioma: revealed by
RT   RNA and targeted exon sequencing.";
RL   J. Thorac. Oncol. 10:844-851(2015).
//