Cellosaurus cell line MM426 (CVCL

Cellosaurus MM426 (CVCL_2609)

[Text version]

Cell line name

MM426

Synonyms

MM 426

Accession

CVCL_2609

Resource Identification Initiative

To cite this cell line use: MM426 (RRID:CVCL_2609)

Comments

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.

Sequence variations

Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=15048078; PubMed=17363583; DepMap=ACH-001570).
Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu88Ter (c.262G>T); ClinVar=VCV000376305; Zygosity=Unspecified (PubMed=9354451; PubMed=17363583; DepMap=ACH-001570).

Disease

Melanoma (NCIt: C3224)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

Age unspecified

Category

Cancer cell line

STR profile

Source(s): CBA=CBA-1352; DepMap=ACH-001570

Markers:

Amelogenin	X,Y
CSF1PO	10,12
D2S1338	21
D3S1358	17
D5S818	9,12
D7S820	8,11
D8S1179	10,16
D13S317	8,11
D16S539	11,13
D18S51	15,18
D19S433	14,15
D21S11	28,30
FGA	23
Penta D	9,11
Penta E	11,14
TH01	8,9
TPOX	8
vWA	15

Publications

PubMed=9354451
Castellano M., Pollock P.M., Walters M.K., Sparrow L.E., Down L.M., Gabrielli B.G., Parsons P.G., Hayward N.K.
CDKN2A/p16 is inactivated in most melanoma cell lines.
Cancer Res. 57:4868-4875(1997)

PubMed=15048078; DOI=10.1038/sj.onc.1207563
Pavey S., Johansson P., Packer L., Taylor J., Stark M.S., Pollock P.M., Walker G.J., Boyle G.M., Harper U., Cozzi S.-J., Hansen K., Yudt L., Schmidt C., Hersey P., Ellem K.A.O., O'Rourke M.G.E., Parsons P.G., Meltzer P.S., Ringner M., Hayward N.K.
Microarray expression profiling in melanoma reveals a BRAF mutation signature.
Oncogene 23:4060-4067(2004)

PubMed=17363583; DOI=10.1158/0008-5472.CAN-06-4152
Stark M.S., Hayward N.K.
Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.
Cancer Res. 67:2632-2642(2007)

PubMed=17516929; DOI=10.1111/j.1600-0749.2007.00375.x
Johansson P., Pavey S., Hayward N.K.
Confirmation of a BRAF mutation-associated gene expression signature in melanoma.
Pigment Cell Res. 20:216-221(2007)

Cross-references

Cell line collections (Providers)

CBA; CBA-1352
ECACC; 10092320

Cell line databases/resources

cancercelllines; CVCL_2609
Cell_Model_Passport; SIDM01382
DepMap; ACH-001570

Biological sample resources

BioSample; SAMN07624430

Encyclopedic resources

Wikidata; Q54906131

Gene expression databases

GEO; GSM170848
GEO; GSM226718

Polymorphism and mutation databases

Cosmic; 889022
Cosmic; 928740
Progenetix; CVCL_2609

Entry history

Entry creation

04-Apr-2012

Last entry update

19-Dec-2024

Version number