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Cellosaurus MM127 (CVCL_2601)

[Text version]
Cell line name MM127
Synonyms MM-127
Accession CVCL_2601
Resource Identification Initiative To cite this cell line use: MM127 (RRID:CVCL_2601)
Comments Problematic cell line: Possibly misclassified. It is not certain that this cell line originate from a metastatic melanoma. Lacks the expression of three protein markers: S100, HMB-45 and Melan-A commonly found in melanoma cell lines (PubMed=27087056). Has a CTNNB1 mutation not seen in other melanoma cell lines (PubMed=11930117).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
Sequence variations
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): CBA; PubMed=27087056

D7S82010,11 (CBA)
10,12 (PubMed=27087056)
Penta D10
Penta E5,10

Run an STR similarity search on this cell line

Goss P.D., Parsons P.G.
The effect of hyperthermia and melphalan on survival of human fibroblast strains and melanoma cell lines.
Cancer Res. 37:152-156(1977)

PubMed=294576; DOI=10.3109/00313027909059039
Muir P.D., Gunz F.W.
A cytogenetic study of eight human melanoma cell lines.
Pathology 11:597-606(1979)

PubMed=460945; DOI=10.3109/00313027909061945
Pope J.H., Morrison L.E., Moss D.J., Parsons P.G., Dunne R.M.
Human malignant melanoma cell lines.
Pathology 11:191-195(1979)

Chenevix-Trench G., Martin N.G., Ellem K.A.O.
Gene expression in melanoma cell lines and cultured melanocytes: correlation between levels of c-src-1, c-myc and p53.
Oncogene 5:1187-1193(1990)

Castellano M., Pollock P.M., Walters M.K., Sparrow L.E., Down L.M., Gabrielli B.G., Parsons P.G., Hayward N.K.
CDKN2A/p16 is inactivated in most melanoma cell lines.
Cancer Res. 57:4868-4875(1997)

PubMed=10070891; DOI=10.1038/sj.bjc.6690147
Zerp S.F., van Elsas A., Peltenburg L.T.C., Schrier P.I.
p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis.
Br. J. Cancer 79:921-926(1999)

PubMed=11930117; DOI=10.1097/00008390-200204000-00013
Pollock P.M., Hayward N.K.
Mutations in exon 3 of the beta-catenin gene are rare in melanoma cell lines.
Melanoma Res. 12:183-186(2002)

PubMed=15048078; DOI=10.1038/sj.onc.1207563
Pavey S., Johansson P., Packer L., Taylor J., Stark M.S., Pollock P.M., Walker G.J., Boyle G.M., Harper U., Cozzi S.-J., Hansen K., Yudt L., Schmidt C., Hersey P., Ellem K.A.O., O'Rourke M.G.E., Parsons P.G., Meltzer P.S., Ringner M., Hayward N.K.
Microarray expression profiling in melanoma reveals a BRAF mutation signature.
Oncogene 23:4060-4067(2004)

PubMed=17363583; DOI=10.1158/0008-5472.CAN-06-4152
Stark M.S., Hayward N.K.
Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.
Cancer Res. 67:2632-2642(2007)

PubMed=17516929; DOI=10.1111/j.1600-0749.2007.00375.x
Johansson P., Pavey S., Hayward N.K.
Confirmation of a BRAF mutation-associated gene expression signature in melanoma.
Pigment Cell Res. 20:216-221(2007)

PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676
Dutton-Regester K., Irwin D., Hunt P., Aoude L.G., Tembe V., Pupo G.M., Lanagan C., Carter C.D., O'Connor L., O'Rourke M., Scolyer R.A., Mann G.J., Schmidt C.W., Herington A., Hayward N.K.
A high-throughput panel for identifying clinically relevant mutation profiles in melanoma.
Mol. Cancer Ther. 11:888-897(2012)

PubMed=27087056; DOI=10.1038/srep24569
Haridas P., McGovern J.A., Kashyap A.S., McElwain D.L.S., Simpson M.J.
Standard melanoma-associated markers do not identify the MM127 metastatic melanoma cell line.
Sci. Rep. 6:24569-24569(2016)

Cell line collections (Providers) CBA; CBA-1344
ECACC; 10092314
Cell line databases/resources cancercelllines; CVCL_2601
Cell_Model_Passport; SIDM01356
DepMap; ACH-001563
Biological sample resources BioSample; SAMN07624422
Encyclopedic resources Wikidata; Q54906044
Gene expression databases GEO; GSM78852
GEO; GSM78853
GEO; GSM78854
GEO; GSM78855
GEO; GSM78856
GEO; GSM78857
GEO; GSM162904
GEO; GSM219416
Polymorphism and mutation databases Cosmic; 873569
Cosmic; 889012
Cosmic; 928705
Cosmic; 2159441
Progenetix; CVCL_2601
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number23