ID   MES-SA/MX2
AC   CVCL_2599
SY   MES-SA/Mx2; MES-SA-MX2; MESSA/MX2; MESSAMX2
DR   CLO; CLO_0007679
DR   ArrayExpress; E-MTAB-38
DR   ATCC; CRL-2274
DR   BioSample; SAMN03471858
DR   cancercelllines; CVCL_2599
DR   Cell_Model_Passport; SIDM01239
DR   IGRhCellID; MESSAMX2
DR   Progenetix; CVCL_2599
DR   Wikidata; Q54905252
RX   PubMed=20215515;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11110; ARID1A; Simple; p.Gly1610Trpfs*38 (c.4826dupC) (p.S1609fs) (c.4825_4826insC); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11110; ARID1A; Simple; p.Thr1690Asnfs*8 (c.5068dupA) (c.5067_5068insA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.His272Thrfs*4 (c.813delT) (p.Phe271fs) (c.811delT); ClinVar=VCV000428208; Zygosity=Heterozygous (from parent cell line).
CC   Omics: SNP array analysis.
CC   Derived from site: In situ; Uterus; UBERON=UBERON_0000995.
ST   Source(s): ATCC=CRL-2274
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 13
ST   D16S539: 11,12
ST   D18S51: 12
ST   D19S433: 14.2,15
ST   D21S11: 29,30.2
ST   D2S1338: 17
ST   D3S1358: 14
ST   D5S818: 13
ST   D7S820: 7,11
ST   D8S1179: 14,15
ST   FGA: 20,25
ST   Penta D: 13,15
ST   Penta E: 7,10
ST   TH01: 6
ST   TPOX: 8,12
ST   vWA: 18
DI   NCIt; C6339; Uterine corpus sarcoma
DI   ORDO; Orphanet_213620; Sarcoma of the corpus uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1404 ! MES-SA
SX   Female
AG   56Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 20
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//