ID   HSG
AC   CVCL_2517
SY   Human Salivary Gland
DR   CLO; CLO_0004263
DR   BioSample; SAMN03151712
DR   BioSample; SAMN03471295
DR   Cosmic; 974319
DR   ECACC; 95031024
DR   JCRB; CHB0004
DR   Wikidata; Q54896445
RX   CelloPub=CLPUB00653;
RX   DOI=10.1007/0-306-46872-7_9;
RX   DOI=10.2330/joralbiosci1965.34.164;
RX   PubMed=2440567;
RX   PubMed=7248901;
RX   PubMed=9183635;
RX   PubMed=16391823;
RX   PubMed=17390010;
RX   PubMed=20143388;
RX   PubMed=29923277;
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=HSG
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=20143388; PubMed=29923277; CelloPub=CLPUB00653). Originally thought to originate from a 54 year old male irradiated submandibular salivary gland.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00313.
CC   Population: African American.
CC   Doubling time: 29 hours (DOI=10.2330/joralbiosci1965.34.164).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Omics: Proteome analysis by 2D-DE/MS.
CC   Discontinued: JCRB; CHB0004; probable.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): CelloPub=CLPUB00653; JCRB; PubMed=29923277
ST   Amelogenin: X
ST   CSF1PO: 9
ST   D13S317: 12,13.3
ST   D16S539: 9,10
ST   D18S51: 16
ST   D21S11: 27,28
ST   D3S1358: 15,18
ST   D5S818: 10,11 (CelloPub=CLPUB00653_sample_Tran; PubMed=29923277)
ST   D5S818: 11 (CelloPub=CLPUB00653_sample_Delporte; JCRB)
ST   D7S820: 8,12
ST   D8S1179: 12,13
ST   FGA: 21
ST   Penta D: 8,15
ST   Penta E: 7,17
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 16,18 (CelloPub=CLPUB00653_sample_Delporte)
ST   vWA: 16,18,19 (CelloPub=CLPUB00653_sample_Tran; JCRB; PubMed=29923277)
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 23
//
RX   CelloPub=CLPUB00653;
RA   Lin L.-C.;
RT   "A new tool in human salivary gland research: the SMG-hu-1 cell line.";
RL   Thesis MDSc (2017), McGill University Montreal, Canada.
//
RX   DOI=10.1007/0-306-46872-7_9;
RA   Sato M.;
RT   "Salivary gland tumors.";
RL   (In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.161-178; Kluwer Academic Publishers; New York (1999).
//
RX   DOI=10.2330/joralbiosci1965.34.164;
RA   Hatakeyama S., Suzuki A.;
RT   "Isolation of salivary adenocarcinoma cell's subclone with in vivo
RT   activity of bone and cartilage fomation in serum-free culture.";
RL   Jpn. J. Oral Biol. 34:164-168(1992).
//
RX   PubMed=2440567;
RA   Sato M., Azuma M., Hayashi Y., Yoshida H., Yanagawa T., Yura Y.;
RT   "5-azacytidine induction of stable myoepithelial and acinar cells from
RT   a human salivary intercalated duct cell clone.";
RL   Cancer Res. 47:4453-4459(1987).
//
RX   PubMed=7248901; DOI=10.1002/1097-0142(19810801)48:3<745::AID-CNCR2820480314>3.0.CO;2-7;
RA   Shirasuna K., Sato M., Miyazaki T.;
RT   "A neoplastic epithelial duct cell line established from an irradiated
RT   human salivary gland.";
RL   Cancer 48:745-752(1981).
//
RX   PubMed=9183635;
RA   Ota M., Kyakumoto S., Sato N.;
RT   "Proliferation and differentiation of human salivary gland
RT   adenocarcinoma cell line HSG.";
RL   Hum. Cell 9:79-88(1996).
//
RX   PubMed=16391823; DOI=10.3892/ijmm.17.2.253;
RA   Kasamatsu A., Uzawa K., Nakashima D., Kouzu Y., Endo Y., Koike H.,
RA   Yokoe H., Harada K., Sato M., Tanzawa H.;
RT   "A proteomics approach to characterizing human submandibular gland
RT   cell lines by fluorescent two-dimensional differential in-gel
RT   electrophoresis.";
RL   Int. J. Mol. Med. 17:253-260(2006).
//
RX   PubMed=17390010; DOI=10.3892/ijo.30.5.1089;
RA   Kawamata H., Omotehara F., Nakashiro K.-i., Uchida D., Shinagawa Y.,
RA   Tachibana M., Imai Y., Fujimori T.;
RT   "Oncogenic mutation of the p53 gene derived from head and neck cancer
RT   prevents cells from undergoing apoptosis after DNA damage.";
RL   Int. J. Oncol. 30:1089-1097(2007).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=29923277; DOI=10.1111/odi.12920;
RA   Lin L.-C., Elkashty O., Ramamoorthi M., Trinh N., Liu Y.-N.,
RA   Sunavala-Dossabhoy G., Pranzatelli T., Michael D.G., Chivasso C.,
RA   Perret J., Chiorini J.A., Delporte C., Tran S.D.;
RT   "Cross-contamination of the human salivary gland HSG cell line with
RT   HeLa cells: a STR analysis study.";
RL   Oral Dis. 24:1477-1483(2018).
//