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Cellosaurus HRT-18 (CVCL_2514)

[Text version]
Cell line name HRT-18
Synonyms HRT18; Human Rectal Tumor-18
Accession CVCL_2514
Resource Identification Initiative To cite this cell line use: HRT-18 (RRID:CVCL_2514)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Microsatellite instability: Instable (MSI) (PubMed=31068700).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (PubMed=12068308; DepMap=ACH-001091).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (DepMap=ACH-001091).
HLA typing Source: CLS=300230
Class I
HLA-AA*02:01:01,24:02:01
HLA-BB*08:01:01,35:01:01
HLA-CC*04:01:01,07:01:01
Class II
HLA-DPDPB1*01:01:01,04:01:01
HLA-DQDQA1*01:04:01,05:01:01
DQB1*02:01:01,05:03:01G
HLA-DRDRB1*03:01:01,14:54:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.15
East Asian, North0.34
East Asian, South1.05
South Asian1.84
European, North63.7
European, South32.91
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3449 (__Parent_cell_line_of_DLD-1/HCT 8/HCT 15/HRT-18)
Children:
CVCL_2515 (HRT-18G)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): ATCC=CCL-244; CLS=300230; ECACC=86040306; IZSLER=BS TCL 26

Markers:
AmelogeninX,Y
CSF1PO12
D2S133817,25
D3S135817
D5S81813
D7S82010,11.3,12 (ATCC=CCL-244)
10,12 (CLS=300230; ECACC=86040306; IZSLER=BS TCL 26)
D8S117915
D13S3178,11
D16S53912,13
D18S5111,17
D19S43314,16
D21S1129,32.2
FGA22
Penta D9,14
Penta E7,14
TH017,9.3
TPOX8,11
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=3349466
Chantret I., Barbat A., Dussaulx E., Brattain M.G., Zweibaum A.
Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines.
Cancer Res. 48:1936-1942(1988)

PubMed=9809040; DOI=10.1016/S0165-4608(98)00081-8
Vermeulen S.J., Chen T.-R., Speleman F., Nollet F., Van Roy F.M., Mareel M.M.
Did the four human cancer cell lines DLD-1, HCT-15, HCT-8, and HRT-18 originate from one and the same patient?
Cancer Genet. Cytogenet. 107:76-79(1998)

PubMed=12068308; DOI=10.1038/nature00766
Davies H.R., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ATCC; CCL-244
BCRJ; 0106
CCLV; CCLV-RIE 0108
CLS; 300230
ECACC; 86040306
IZSLER; BS TCL 26
Cell line databases/resources CLO; CLO_0003668
CLO; CLO_0003836
CLDB; cl1710
CLDB; cl1711
cancercelllines; CVCL_2514
Cell_Model_Passport; SIDM00788
ColonAtlas; HRT18
DepMap; ACH-001091
LINCS_LDP; LCL-1289
Anatomy/cell type resources BTO; BTO_0001947
Biological sample resources BioSample; SAMN03471480
BioSample; SAMN10989582
Chemistry resources ChEMBL-Cells; CHEMBL3308672
ChEMBL-Targets; CHEMBL614834
PharmacoDB; HRT18_567_2019
PubChem_Cell_line; CVCL_2514
Encyclopedic resources Wikidata; Q54895337
Gene expression databases GEO; GSM827431
Polymorphism and mutation databases Cosmic; 724841
Progenetix; CVCL_2514
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number33