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Cellosaurus HRA-19a1.1 Alpha2Alpha1 E (CVCL_2511)

[Text version]
Cell line name HRA-19a1.1 Alpha2Alpha1 E
Accession CVCL_2511
Resource Identification Initiative To cite this cell line use: HRA-19a1.1 Alpha2Alpha1 E (RRID:CVCL_2511)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6137; ITGA2 (Note=Chimeric extracellular and TM domain of ITGA2 and the cytoplasmic domain of ITGA1).
Derived from site: In situ; Rectum; UBERON=UBERON_0001052.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Arg405Ter (c.1213C>T); ClinVar=VCV000127275; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Arg1450Ter (c.4348C>T); ClinVar=VCV000194585; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:914; B2M; Simple; p.Ser16Alafs*27 (c.42_45delTCTT); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Disease Rectal adenocarcinoma (NCIt: C9383)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2509 (HRA-19a1.1)
Sex of cell Male
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): ECACC=09071527

Markers:
AmelogeninX,Y
CSF1PO12
D5S81811
D7S8209,12
D13S31711,12
D16S53911
TH018
TPOX11
vWA16

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Publications

PubMed=18664572; DOI=10.1074/jbc.M802932200; PMCID=PMC2562061
Kirkland S.C., Ying H.-J.
Alpha2beta1 integrin regulates lineage commitment in multipotent human colorectal cancer cells.
J. Biol. Chem. 283:27612-27619(2008)

Cross-references
Cell line collections (Providers) ECACC; 09071527
Cell line databases/resources cancercelllines; CVCL_2511
Encyclopedic resources Wikidata; Q54895219
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number20