ID   HMT-3522 S1
AC   CVCL_2499
SY   HMT-3522-S1; HMT-3522S1; HMT3522S1; S1; S-1; HMT-3522/wt
DR   BTO; BTO:0006484
DR   EFO; EFO_0001191
DR   ArrayExpress; E-TABM-244
DR   Cosmic; 889085
DR   ECACC; 98102210
DR   GEO; GSM1219374
DR   GEO; GSM1219375
DR   GEO; GSM1219376
DR   GEO; GSM1219377
DR   GEO; GSM1219378
DR   LINCS_HMS; 51119
DR   PharmacoDB; S1_1340_2019
DR   PRIDE; PXD000309
DR   Wikidata; Q54889968
RX   PubMed=7982476;
RX   PubMed=8616848;
RX   PubMed=18316601;
RX   PubMed=18516279;
RX   PubMed=22414580;
RX   PubMed=24176112;
CC   Part of: JWGray breast cancer cell line panel.
CC   Population: Caucasian.
CC   Doubling time: 40.14 hours (JWGray panel).
CC   Omics: Deep proteome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Donor information: Established from a nontumorigenic fibrocystic breast lesion (from parent cell line).
CC   Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008359.
CC   Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6855 ! HMT-3522
SX   Female
AG   50Y
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 19
RX   PubMed=7982476; DOI=10.1006/excr.1994.1355;
RA   Moyret C., Madsen M.W., Cooke J., Briand P., Theillet C.;
RT   "Gradual selection of a cellular clone presenting a mutation at codon
RT   179 of the p53 gene during establishment of the immortalized human
RT   breast epithelial cell line HMT-3522.";
RL   Exp. Cell Res. 215:380-385(1994).
RX   PubMed=8616848;
RA   Briand P., Nielsen K.V., Madsen M.W., Petersen O.W.;
RT   "Trisomy 7p and malignant transformation of human breast epithelial
RT   cells following epidermal growth factor withdrawal.";
RL   Cancer Res. 56:2039-2044(1996).
RX   PubMed=18316601; DOI=10.1158/0008-5472.CAN-07-2225;
RA   Rizki A., Weaver V.M., Lee S.-Y., Rozenberg G.I., Chin K., Myers C.A.,
RA   Bascom J.L., Mott J.D., Semeiks J.R., Grate L.R., Mian I.S.,
RA   Borowsky A.D., Jensen R.A., Idowu M.O., Chen F.-Q., Chen D.J.,
RA   Petersen O.W., Gray J.W., Bissell M.J.;
RT   "A human breast cell model of preinvasive to invasive transition.";
RL   Cancer Res. 68:1378-1387(2008).
RX   PubMed=18516279; DOI=10.1016/j.molonc.2007.02.004;
RA   Kenny P.A., Lee G.Y., Myers C.A., Neve R.M., Semeiks J.R.,
RA   Spellman P.T., Lorenz K., Lee E.H., Barcellos-Hoff M.H.,
RA   Petersen O.W., Gray J.W., Bissell M.J.;
RT   "The morphologies of breast cancer cell lines in three-dimensional
RT   assays correlate with their profiles of gene expression.";
RL   Mol. Oncol. 1:84-96(2007).
RX   PubMed=22414580; DOI=10.1158/0008-5472.CAN-11-3711;
RA   Geiger T., Madden S.F., Gallagher W.M., Cox J., Mann M.;
RT   "Proteomic portrait of human breast cancer progression identifies
RT   novel prognostic markers.";
RL   Cancer Res. 72:2428-2439(2012).
RX   PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110;
RA   Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M.,
RA   Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S.,
RA   Huh N., Chung J., Cope L., Fackler M.J., Umbricht C.B., Sukumar S.,
RA   Seth P., Sukhatme V.P., Jakkula L.R., Lu Y.-L., Mills G.B., Cho R.J.,
RA   Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.;
RT   "Modeling precision treatment of breast cancer.";
RL   Genome Biol. 14:R110.1-R110.14(2013).