Cell line name |
H33HJ-JA1 |
Accession |
CVCL_2461 |
Resource Identification Initiative |
To cite this cell line use: H33HJ-JA1 (RRID:CVCL_2461) |
Comments |
Group: Patented cell line. Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8163. Population: Caucasian. Omics: SNP array analysis. Misspelling: H33Hj-A1; KCB=KCB 2016015YJ. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0065 (Jurkat) |
Sex of cell |
Male |
Age at sampling |
14Y |
Category |
Cancer cell line |
STR profile |
Source(s): ATCC=CRL-8163
Markers: Run an STR similarity search on this cell line |
Publications | PubMed=7592872; DOI=10.1074/jbc.270.44.26533 Fargnoli J., Burkhardt A.L., Laverty M., Kut S.A., van Oers N.S.C., Weiss A., Bolen J.B. Syk mutation in Jurkat E6-derived clones results in lack of p72syk expression. J. Biol. Chem. 270:26533-26537(1995) Patent=US5597901 Stern A.S. Homogeneous human interleukin 2. Patent number US5597901, 28-Jan-1997 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662 Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A. A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 70:2158-2164(2010) |
Cross-references |
Cell line collections (Providers) |
ATCC; CRL-8163
ECACC; 90112119
KCB; KCB 2016015YJ
|
Cell line databases/resources |
CLO; CLO_0003593
CLDB; cl1542
cancercelllines; CVCL_2461
CCRID; 5301HUM-KCB16015YJ
LINCS_LDP; LCL-2037
|
Biological sample resources |
BioSample; SAMN03471197
|
Encyclopedic resources |
Wikidata; Q54872070
|
Gene expression databases |
GEO; GSM827363
|
Polymorphism and mutation databases |
Cosmic; 683537
IARC_TP53; 21354
Progenetix; CVCL_2461
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 19-Dec-2024 |
Version number | 28 |
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