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Cellosaurus h1RPE7 (CVCL_2459)

[Text version]
Cell line name h1RPE7
Synonyms h1RPE-7
Accession CVCL_2459
Resource Identification Initiative To cite this cell line use: h1RPE7 (RRID:CVCL_2459)
Comments Doubling time: ~24 hours (ECACC=09061602).
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Genetic integration: Method=Transfection; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Eye, retina, retinal pigment epithelium; UBERON=UBERON_0001782.
Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_9W31 ! h1RPE116
Sex of cell Female
Age at sampling 50Y
Category Transformed cell line
STR profile Source(s): ECACC=09061602

Markers:
AmelogeninX
CSF1PO10,13
D5S8189,13
D7S8209,10
D13S31712
D16S53912
TH017,9.3
TPOX8
vWA16,19

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Publications

PubMed=11504951; DOI=10.1073/pnas.171266298; PMCID=PMC55557
Raymond Douglas Lund, Peter Adamson, Yves Sauve, David J. Keegan, Sergej V. Girman, Shao-Mei Wang, Helen L. Winton, Naheed Kanuga, Anthony S.L. Kwan, Laurence Beauchene, Anne Zerbib ...Show all 15 authors... , Len Hetherington, Pierre-Olivier Couraud, Peter J. Coffey, John Greenwood; Show fewer authors
Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats.
Proc. Natl. Acad. Sci. U.S.A. 98:9942-9947(2001)

PubMed=11818403
Naheed Kanuga, Helen L. Winton, Laurence Beauchene, Ahmet Koman, Anne Zerbib, Stephanie Halford, Pierre-Olivier Couraud, David J. Keegan, Peter J. Coffey, Raymond Douglas Lund, Peter Adamson, John Greenwood;
Characterization of genetically modified human retinal pigment epithelial cells developed for in vitro and transplantation studies.
Invest. Ophthalmol. Vis. Sci. 43:546-555(2002)

PubMed=25177495; DOI=10.1155/2014/801787; PMCID=PMC4142280
Alla V. Kuznetsova, Alexander M. Kurinov, Maria A. Aleksandrova;
Cell models to study regulation of cell transformation in pathologies of retinal pigment epithelium.
J. Ophthalmol. 2014:801787.1-801787.18(2014)

Cross-references
Cell line collections (Providers) ECACC; 09061602
Encyclopedic resources Wikidata; Q54871994
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number18