ID   Detroit 6
AC   CVCL_2436
SY   Detroit-6; Det-6; Det6
DR   CLO; CLO_0002754
DR   CLDB; cl1039
DR   CLDB; cl1040
DR   ATCC; CCL-3
DR   BioSample; SAMN03151685
DR   IZSLER; BS CL 26
DR   Wikidata; Q54831004
RX   DOI=10.1007/BF02618370;
RX   PubMed=1246601;
RX   PubMed=4864103;
RX   PubMed=5641128;
RX   PubMed=5668122;
RX   PubMed=13307201;
RX   PubMed=13370509;
RX   PubMed=13460970;
RX   PubMed=14185313;
RX   PubMed=20143388;
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=4864103; PubMed=5641128; PubMed=1246601; PubMed=20143388). Originally thought to originate from the bone marrow of a 58 year old male lung carcinoma patient.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00004.
CC   Population: African American.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Discontinued: ATCC; CCL-3; true.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): IZSLER
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D13S317: 14
ST   D16S539: 9,10
ST   D21S11: 27,28
ST   D5S818: 11,12
ST   D7S820: 12
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 16,18
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 25
//
RX   DOI=10.1007/BF02618370;
RA   Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.;
RT   "The animal cell culture collection.";
RL   In Vitro 5:1-16(1970).
//
RX   PubMed=1246601; DOI=10.1126/science.1246601;
RA   Nelson-Rees W.A., Flandermeyer R.R.;
RT   "HeLa cultures defined.";
RL   Science 191:96-98(1976).
//
RX   PubMed=4864103;
RA   Gartler S.M.;
RT   "Genetic markers as tracers in cell culture.";
RL   Natl. Cancer Inst. Monogr. 26:167-195(1967).
//
RX   PubMed=5641128; DOI=10.1038/217750a0;
RA   Gartler S.M.;
RT   "Apparent Hela cell contamination of human heteroploid cell lines.";
RL   Nature 217:750-751(1968).
//
RX   PubMed=5668122; DOI=10.3181/00379727-128-33119;
RA   Peterson W.D. Jr., Stulberg C.S., Swanborg N.K., Robinson A.R.;
RT   "Glucose-6-phosphate dehydrogenase isoenzymes in human cell cultures
RT   determined by sucrose-agar gel and cellulose acetate zymograms.";
RL   Proc. Soc. Exp. Biol. Med. 128:772-776(1968).
//
RX   PubMed=13307201;
RA   Berman L., Stulberg C.S., Ruddle F.H.;
RT   "Epithelium-like cells derived from tissue cultures of human bone
RT   marrow and ascitic fluid.";
RL   J. Mich. State Med. Soc. 55:269-271(1956).
//
RX   PubMed=13370509; DOI=10.3181/00379727-92-22595;
RA   Berman L., Stulberg C.S.;
RT   "Eight culture strains (Detroit) of human epithelial-like cells.";
RL   Proc. Soc. Exp. Biol. Med. 92:730-735(1956).
//
RX   PubMed=13460970;
RA   Berman L., Stulberg C.S., Ruddle F.H.;
RT   "Human cell culture: morphology of the Detroit strains.";
RL   Cancer Res. 17:668-676(1957).
//
RX   PubMed=14185313; DOI=10.1126/science.146.3641.241;
RG   Cell Culture Collection Committee;
RT   "Animal cell strains. The Cell Culture Collection Committee has
RT   assembled and certified 23 strains of animal cells.";
RL   Science 146:241-243(1964).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//