ID   BICR 18
AC   CVCL_2309
SY   BICR-18; BICR_18; BICR18; BICR-18 R; Beatson Institute for Cancer Research 18
DR   CLDB; cl7215
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN10987721
DR   cancercelllines; CVCL_2309
DR   CancerTools; 152843
DR   Cell_Model_Passport; SIDM01519
DR   Cosmic; 2588351
DR   DepMap; ACH-000992
DR   ECACC; 06051601
DR   GEO; GSM886884
DR   GEO; GSM887949
DR   IARC_TP53; 30020
DR   ICLC; HTL10003
DR   LiGeA; CCLE_387
DR   PharmacoDB; BICR18_95_2019
DR   Progenetix; CVCL_2309
DR   Wikidata; Q54796524
DR   Ximbio; 152843
RX   PubMed=7646764;
RX   PubMed=8390283;
RX   PubMed=9150362;
RX   PubMed=22460905;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Problematic cell line: Partially contaminated. The ICLC stock (now discontinued) was found to be contaminated, probably by U-251MG (Cellosaurus=CVCL_0021).
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=6.55%; Native American=0%; East Asian, North=7.21%; East Asian, South=0%; South Asian=0%; European, North=48.15%; European, South=38.08% (PubMed=30894373).
CC   Discontinued: ECACC; 06051601; true.
CC   Discontinued: ICLC; HTL10003; true.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
ST   Source(s): ECACC=06051601
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 8,13
ST   D16S539: 12,14
ST   D21S11: 29
ST   D5S818: 12
ST   D7S820: 9
ST   TH01: 7
ST   TPOX: 9,12
ST   vWA: 17,20
DI   NCIt; C4044; Laryngeal squamous cell carcinoma
DI   ORDO; Orphanet_494550; Squamous cell carcinoma of the larynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 27
//
RX   PubMed=8390283; DOI=10.1038/bjc.1993.238; PMCID=PMC1968513;
RA   Burns, Julie E.
RA   Baird, M.C.
RA   Clark, Louise J.
RA   Burns, Philip A.
RA   Edington, Kirsten Gilian
RA   Chapman, Charlotte
RA   Mitchell, Roy
RA   Robertson, Gordon
RA   Soutar, David
RA   Parkinson, Eric Kenneth
RT   "Gene mutations and increased levels of p53 protein in human squamous
RT   cell carcinomas and their cell lines.";
RL   Br. J. Cancer 67:1274-1284(1993).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=9150362; DOI=10.1038/sj.onc.1201028;
RA   Loughran, Oonagh P.
RA   Clark, Louise J.
RA   Bond, Jacquelyn
RA   Baker, Angela
RA   Berry, Isabella J.
RA   Edington, Kirsten Gilian
RA   Ly, I.-S.
RA   Simmons, R.
RA   Haw, Robin
RA   Black, Donald M.
RA   Newbold, Robert F.
RA   Parkinson, Eric Kenneth
RT   "Evidence for the inactivation of multiple replicative lifespan genes
RT   in immortal human squamous cell carcinoma keratinocytes.";
RL   Oncogene 14:1955-1964(1997).
//
RX   PubMed=7646764; DOI=10.1002/mc.2940130408;
RA   Edington, Kirsten Gilian
RA   Loughran, Oonagh P.
RA   Berry, Isabella J.
RA   Parkinson, Eric Kenneth
RT   "Cellular immortality: a late event in the progression of human
RT   squamous cell carcinoma of the head and neck associated with p53
RT   alteration and a high frequency of allele loss.";
RL   Mol. Carcinog. 13:254-265(1995).
//