ID   BICR 10
AC   CVCL_2307
SY   BICR-10; BICR10; BICR-10 R; Beatson Institute for Cancer Research 10
DR   CLO; CLO_0009941
DR   EFO; EFO_0006540
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-3610
DR   BioGRID_ORCS_Cell_line; 835
DR   BioSample; SAMN03473143
DR   cancercelllines; CVCL_2307
DR   CancerTools; 152841
DR   Cell_Model_Passport; SIDM00077
DR   Cosmic-CLP; 1290724
DR   DepMap; ACH-001331
DR   ECACC; 04072103
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   GDSC; 1290724
DR   GEO; GSM827321
DR   GEO; GSM1669621
DR   LINCS_LDP; LCL-1203
DR   PharmacoDB; BICR10_93_2019
DR   Progenetix; CVCL_2307
DR   Wikidata; Q54796517
DR   Ximbio; 152841
RX   PubMed=7646764;
RX   PubMed=8390283;
RX   PubMed=9307265;
RX   PubMed=10523844;
RX   PubMed=20215515;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=30971826;
RX   PubMed=31321735;
RX   PubMed=32990596;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   HLA typing: A*01:01,01:01; B*14:01,44:02; C*01:02,07:06 (PubMed=26589293).
CC   Karyotypic information: Near diploid karyotype (PubMed=31321735).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.05%; Native American=0%; East Asian, North=0.01%; East Asian, South=0%; South Asian=0.82%; European, North=71.25%; European, South=27.87% (PubMed=30894373).
CC   Discontinued: ECACC; 04072103; true.
CC   Derived from site: In situ; Oral cavity, buccal mucosa; UBERON=UBERON_0006956.
ST   Source(s): Cosmic-CLP=1290724; ECACC=04072103; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 12,14
ST   D13S317: 8,14
ST   D16S539: 9,13
ST   D18S51: 14,19
ST   D21S11: 30.2,32.2
ST   D3S1358: 17
ST   D5S818: 11,13
ST   D7S820: 11,12
ST   D8S1179: 13,14
ST   FGA: 21,22
ST   Penta D: 9,12
ST   Penta E: 7,18
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C4040; Buccal mucosa squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 34
//
RX   PubMed=32990596; DOI=10.7554/eLife.57761; PMCID=PMC7591259;
RA   Chai, Annie Wai-Yeeng
RA   Yee, Pei-San
RA   Price, Stacey
RA   Yee, Shi-Mun
RA   Lee, Hui-Mei
RA   Tiong, Vivian K.H.
RA   Goncalves, Emanuel
RA   Behan, Fiona M.
RA   Bateson, Jessica
RA   Gilbert, James G.R.
RA   Tan, Aik-Choon
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RA   Cheong, Sok-Ching
RT   "Genome-wide CRISPR screens of oral squamous cell carcinoma reveal
RT   fitness genes in the Hippo pathway.";
RL   eLife 9:e57761.1-e57761.34(2020).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=8390283; DOI=10.1038/bjc.1993.238; PMCID=PMC1968513;
RA   Burns, Julie E.
RA   Baird, M.C.
RA   Clark, Louise J.
RA   Burns, Philip A.
RA   Edington, Kirsten Gilian
RA   Chapman, Charlotte
RA   Mitchell, Roy
RA   Robertson, Gordon
RA   Soutar, David
RA   Parkinson, Eric Kenneth
RT   "Gene mutations and increased levels of p53 protein in human squamous
RT   cell carcinomas and their cell lines.";
RL   Br. J. Cancer 67:1274-1284(1993).
//
RX   PubMed=10523844; DOI=10.1038/sj.onc.1202957;
RA   Agochiya, Mahima
RA   Brunton, Valerie G.
RA   Owens, Dewi W.
RA   Parkinson, Eric Kenneth
RA   Paraskeva, Christos
RA   Keith, William Nicol
RA   Frame, Margaret Catherine
RT   "Increased dosage and amplification of the focal adhesion kinase gene
RT   in human cancer cells.";
RL   Oncogene 18:5646-5653(1999).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31321735; DOI=10.1007/s13258-019-00850-6;
RA   Ribeiro, Ilda Patricia
RA   Rodrigues, Joana M.
RA   Mascarenhas, Alexandra
RA   Marques, Vanessa
RA   Caramelo, Francisco
RA   Juliao, Maria J.
RA   Liehr, Thomas
RA   Melo, Joana Barbosa
RA   Carreira, Isabel Marques
RT   "(Cyto)genomic and epigenetic characterization of BICR 10 cell line
RT   and three new established primary human head and neck squamous cell
RT   carcinoma cultures.";
RL   Genes Genomics 41:1207-1221(2019).
//
RX   PubMed=7646764; DOI=10.1002/mc.2940130408;
RA   Edington, Kirsten Gilian
RA   Loughran, Oonagh P.
RA   Berry, Isabella J.
RA   Parkinson, Eric Kenneth
RT   "Cellular immortality: a late event in the progression of human
RT   squamous cell carcinoma of the head and neck associated with p53
RT   alteration and a high frequency of allele loss.";
RL   Mol. Carcinog. 13:254-265(1995).
//
RX   PubMed=9307265;
RA   McGregor, Fiona
RA   Wagner, Eric
RA   Felix, David H.
RA   Soutar, David
RA   Parkinson, Eric Kenneth
RA   Harrison, Paul Robert
RT   "Inappropriate retinoic acid receptor-beta expression in oral
RT   dysplasias: correlation with acquisition of the immortal phenotype.";
RL   Cancer Res. 57:3886-3889(1997).
//
RX   PubMed=30971826; DOI=10.1038/s41586-019-1103-9;
RA   Behan, Fiona M.
RA   Iorio, Francesco
RA   Picco, Gabriele
RA   Goncalves, Emanuel
RA   Beaver, Charlotte M.
RA   Migliardi, Giorgia
RA   Santos, Rita
RA   Rao, Yanhua
RA   Sassi, Francesco
RA   Pinnelli, Marika
RA   Ansari, Rizwan
RA   Harper, Sarah
RA   Jackson, David Adam
RA   McRae, Rebecca
RA   Pooley, Rachel
RA   Wilkinson, Piers
RA   van der Meer, Dieudonne J.
RA   Dow, David
RA   Buser-Doepner, Carolyn A.
RA   Bertotti, Andrea
RA   Trusolino, Livio
RA   Stronach, Euan Alexander
RA   Saez-Rodriguez, Julio
RA   Yusa, Kosuke
RA   Garnett, Mathew J.
RT   "Prioritization of cancer therapeutic targets using CRISPR-Cas9
RT   screens.";
RL   Nature 568:511-516(2019).
//