ID   A375-C6
AC   CVCL_2295
DR   CLO; CLO_0037118
DR   cancercelllines; CVCL_2295
DR   ECACC; 97011321
DR   GEO; GSM827328
DR   LINCS_LDP; LCL-1284
DR   Progenetix; CVCL_2295
DR   Wikidata; Q54606779
RX   PubMed=2584706;
RX   PubMed=20215515;
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=A375-C6
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Omics: SNP array analysis.
CC   Misspelling: A373-C6; CLO=CLO_0037118; Note=Also in Sigma-Aldrich catalog.
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
ST   Source(s): ECACC=97011321
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 11
ST   D16S539: 9
ST   D5S818: 12
ST   D7S820: 9
ST   TH01: 8
ST   TPOX: 8,10
ST   vWA: 16,17
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0132 ! A-375
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 27
//
RX   PubMed=2584706; DOI=10.4049/jimmunol.143.11.3538;
RA   Morinaga Y., Suzuki H., Takatsuki F., Akiyama Y., Taniyama T.,
RA   Matsushima K., Onozaki K.;
RT   "Contribution of IL-6 to the antiproliferative effect of IL-1 and
RT   tumor necrosis factor on tumor cell lines.";
RL   J. Immunol. 143:3538-3542(1989).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//