ID   1BR3
AC   CVCL_2279
SY   1BR.3; 1.BR3; 1BR; 1Br; 1 BRighton
DR   CLO; CLO_0001157
DR   EFO; EFO_0022560
DR   CLDB; cl31
DR   ECACC; 90011801
DR   Wikidata; Q54582783
RX   DOI=10.1007/978-1-4757-1117-2_12;
RX   PubMed=837385;
RX   PubMed=1196376;
RX   PubMed=1214825;
RX   PubMed=1372096;
RX   PubMed=2400879;
RX   PubMed=2903889;
RX   PubMed=2973075;
RX   PubMed=6408472;
RX   PubMed=6600729;
RX   PubMed=7067035;
RX   PubMed=7360141;
RX   PubMed=7471106;
RX   PubMed=7882314;
RX   PubMed=8609460;
RX   PubMed=8823375;
RX   PubMed=10022907;
RX   PubMed=10987302;
RX   PubMed=11219864;
RX   PubMed=11416159;
RX   PubMed=12082606;
RX   PubMed=12604777;
RX   PubMed=15130666;
RX   PubMed=15574327;
RX   PubMed=16714754;
RX   PubMed=19179371;
CC   Doubling time: 24 hours (PubMed=8609460).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
ST   Source(s): PubMed=11416159
ST   Amelogenin: X,Y
ST   D18S51: 12,14
ST   D21S11: 30
ST   D8S1179: 12,14
ST   FGA: 21,22
ST   TH01: 6,9.3
ST   vWA: 14,15
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   23Y
CA   Finite cell line
DT   Created: 04-04-12; Last updated: 10-09-24; Version: 21
//
RX   DOI=10.1007/978-1-4757-1117-2_12;
RA   Arlett C.F., Harcourt S.A.;
RT   "The mutagen sensitivity response of cells from individuals
RT   heterozygous for DNA repair deficiency genes.";
RL   (In book chapter) The use of human cells for the evaluation of risk from physical and chemical agents; Castellani A. (eds.); pp.155-167; Springer; Boston; USA (1983).
//
RX   PubMed=837385;
RA   Lehmann A.R., Kirk-Bell S., Arlett C.F., Harcourt S.A.,
RA   de Weerd-Kastelein E.A., Keijzer W., Hall-Smith P.;
RT   "Repair of ultraviolet light damage in a variety of human fibroblast
RT   cell strains.";
RL   Cancer Res. 37:904-910(1977).
//
RX   PubMed=1196376; DOI=10.1038/258427a0;
RA   Taylor A.M.R., Harnden D.G., Arlett C.F., Harcourt S.A., Lehmann A.R.,
RA   Stevens S., Bridges B.A.;
RT   "Ataxia telangiectasia: a human mutation with abnormal radiation
RT   sensitivity.";
RL   Nature 258:427-429(1975).
//
RX   PubMed=1214825; DOI=10.1016/0027-5107(75)90209-2;
RA   Arlett C.F., Harcourt S.A., Broughton B.C.;
RT   "The influence of caffeine on cell survival in excision-proficient and
RT   excision-deficient xeroderma pigmentosum and normal human cell strains
RT   following ultraviolet-light irradiation.";
RL   Mutat. Res. 33:341-346(1975).
//
RX   PubMed=1372096; DOI=10.1016/0921-8777(92)90074-d;
RA   Arlett C.F., Harcourt S.A., Cole J., Green M.H.L., Anstey A.V.;
RT   "A comparison of the response of unstimulated and stimulated
RT   T-lymphocytes and fibroblasts from normal, xeroderma pigmentosum and
RT   trichothiodystrophy donors to the lethal action of UV-C.";
RL   Mutat. Res. 273:127-135(1992).
//
RX   PubMed=2400879; DOI=10.1259/0007-1285-63-752-624;
RA   Plowman P.N., Bridges B.A., Arlett C.F., Hinney A., Kingston J.E.;
RT   "An instance of clinical radiation morbidity and cellular
RT   radiosensitivity, not associated with ataxia-telangiectasia.";
RL   Br. J. Radiol. 63:624-628(1990).
//
RX   PubMed=2903889; DOI=10.1080/09553008814552321;
RA   Arlett C.F., Green M.H.L., Priestley A., Harcourt S.A., Mayne L.V.;
RT   "Comparative human cellular radiosensitivity: I. The effect of SV40
RT   transformation and immortalisation on the gamma-irradiation survival
RT   of skin derived fibroblasts from normal individuals and from
RT   ataxia-telangiectasia patients and heterozygotes.";
RL   Int. J. Radiat. Biol. 54:911-928(1988).
//
RX   PubMed=2973075; DOI=10.2307/3577479;
RA   Fertil B., Deschavanne P.J., Debieu D., Malaise E.-P.;
RT   "Correlation between PLD repair capacity and the survival curve of
RT   human fibroblasts in exponential growth phase: analysis in terms of
RT   several parameters.";
RL   Radiat. Res. 116:74-88(1988).
//
RX   PubMed=6408472; DOI=10.1016/0027-5107(83)90177-X;
RA   Teo I.A., Arlett C.F., Harcourt S.A., Priestley A., Broughton B.C.;
RT   "Multiple hypersensitivity to mutagens in a cell strain (46BR) derived
RT   from a patient with immuno-deficiencies.";
RL   Mutat. Res. 107:371-386(1983).
//
RX   PubMed=6600729; DOI=10.1080/09553008314550171;
RA   Arlett C.F., Priestley A.;
RT   "Defective recovery from potentially lethal damage in some human
RT   fibroblast cell strains.";
RL   Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 43:157-167(1983).
//
RX   PubMed=7067035; DOI=10.1093/carcin/3.1.33;
RA   Teo I.A., Arlett C.F.;
RT   "The response of a variety of human fibroblast cell strains to the
RT   lethal effects of alkylating agents.";
RL   Carcinogenesis 3:33-37(1982).
//
RX   PubMed=7360141; DOI=10.1016/0027-5107(80)90180-3;
RA   Marshall R.R., Arlett C.F., Harcourt S.A., Broughton B.C.;
RT   "Increased sensitivity of cell strains from Cockayne's syndrome to
RT   sister-chromatid-exchange induction and cell killing by UV light.";
RL   Mutat. Res. 69:107-112(1980).
//
RX   PubMed=7471106;
RA   Arlett C.F., Harcourt S.A.;
RT   "Survey of radiosensitivity in a variety of human cell strains.";
RL   Cancer Res. 40:926-932(1980).
//
RX   PubMed=7882314;
RA   Badie C., Iliakis G., Foray N., Alsbeih G.A., Pantellias G.E.,
RA   Okayasu R., Cheong N., Russell N.S., Begg A.C., Arlett C.F.,
RA   Malaise E.-P.;
RT   "Defective repair of DNA double-strand breaks and chromosome damage in
RT   fibroblasts from a radiosensitive leukemia patient.";
RL   Cancer Res. 55:1232-1234(1995).
//
RX   PubMed=8609460; DOI=10.1080/095530096146075;
RA   Alsbeih G.A., Fertil B., Arlett C.F., Malaise E.-P.;
RT   "High split-dose recovery in hypersensitive human fibroblasts: a case
RT   of induced radioresistance?";
RL   Int. J. Radiat. Biol. 69:225-239(1996).
//
RX   PubMed=8823375; DOI=10.1111/1523-1747.ep12584287;
RA   Moriwaki S.-i., Stefanini M., Lehmann A.R., Hoeijmakers J.H.J.,
RA   Robbins J.H., Rapin I., Botta E., Tanganelli B., Vermeulen W.,
RA   Broughton B.C., Kraemer K.H.;
RT   "DNA repair and ultraviolet mutagenesis in cells from a new patient
RT   with xeroderma pigmentosum group G and Cockayne syndrome resemble
RT   xeroderma pigmentosum cells.";
RL   J. Invest. Dermatol. 107:647-653(1996).
//
RX   PubMed=10022907; DOI=10.1128/mcb.19.3.2206; PMCID=PMC84013;
RA   Cordonnier A.M., Lehmann A.R., Fuchs R.P.P.;
RT   "Impaired translesion synthesis in xeroderma pigmentosum variant
RT   extracts.";
RL   Mol. Cell. Biol. 19:2206-2211(1999).
//
RX   PubMed=10987302;
RA   Girard P.-M., Foray N., Stumm M., Waugh A.P.W., Riballo E., Maser R.S.,
RA   Phillips W.P., Petrini J.H.J., Arlett C.F., Jeggo P.A.;
RT   "Radiosensitivity in Nijmegen breakage syndrome cells is attributable
RT   to a repair defect and not cell cycle checkpoint defects.";
RL   Cancer Res. 60:4881-4888(2000).
//
RX   PubMed=11219864; DOI=10.1093/carcin/1.9.745;
RA   Arlett C.F., Harcourt S.A., Lehmann A.R., Stevens S.,
RA   Ferguson-Smith M.A., Morley W.N.;
RT   "Studies on a new case of xeroderma pigmentosum (XP3BR) from
RT   complementation group G with cellular sensitivity to ionizing
RT   radiation.";
RL   Carcinogenesis 1:745-751(1980).
//
RX   PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459;
RA   Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G.,
RA   Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R.,
RA   Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.;
RT   "Short tandem repeat profiling provides an international reference
RT   standard for human cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
//
RX   PubMed=12082606; DOI=10.1038/sj.onc.1205596;
RA   Girard P.-M., Riballo E., Begg A.C., Waugh A.P.W., Jeggo P.A.;
RT   "Nbs1 promotes ATM dependent phosphorylation events including those
RT   required for G1/S arrest.";
RL   Oncogene 21:4191-4199(2002).
//
RX   PubMed=12604777; DOI=10.1073/pnas.0437964100; PMCID=PMC151363;
RA   Dai Y., Kysela B., Hanakahi L.A., Manolis K., Riballo E., Stumm M.,
RA   Harville T.O., West S.C., Oettinger M.A., Jeggo P.A.;
RT   "Nonhomologous end joining and V(D)J recombination require an
RT   additional factor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:2462-2467(2003).
//
RX   PubMed=15130666; DOI=10.1016/j.exger.2004.02.002;
RA   Bridger J.M., Kill I.R.;
RT   "Aging of Hutchinson-Gilford progeria syndrome fibroblasts is
RT   characterised by hyperproliferation and increased apoptosis.";
RL   Exp. Gerontol. 39:717-724(2004).
//
RX   PubMed=15574327; DOI=10.1016/j.molcel.2004.10.029;
RA   Riballo E., Kuhne M., Rief N., Doherty A., Smith G.C.M., Recio M.-J.,
RA   Reis C., Dahm K., Fricke A., Krempler A., Parker A.R., Jackson S.P.,
RA   Gennery A.R., Jeggo P.A., Lobrich M.;
RT   "A pathway of double-strand break rejoining dependent upon ATM,
RT   Artemis, and proteins locating to gamma-H2AX foci.";
RL   Mol. Cell 16:715-724(2004).
//
RX   PubMed=16714754; DOI=10.1259/bjr/83726649;
RA   Arlett C.F., Plowman P.N., Rogers P.B., Parris C.N., Abbaszadeh F.,
RA   Green M.H.L., McMillan T.J., Bush C., Foray N., Lehmann A.R.;
RT   "Clinical and cellular ionizing radiation sensitivity in a patient
RT   with xeroderma pigmentosum.";
RL   Br. J. Radiol. 79:510-517(2006).
//
RX   PubMed=19179371; DOI=10.1093/nar/gkp023; PMCID=PMC2651789;
RA   Limsirichaikul S., Niimi A., Fawcett H., Lehmann A.R., Yamashita S.,
RA   Ogi T.;
RT   "A rapid non-radioactive technique for measurement of repair synthesis
RT   in primary human fibroblasts by incorporation of ethynyl deoxyuridine
RT   (EdU).";
RL   Nucleic Acids Res. 37:e31.1-e31.10(2009).
//