ID   180BR
AC   CVCL_2278
AS   CVCL_7643
SY   180 BRighton; GM16088
DR   BTO; BTO:0004314
DR   CLO; CLO_0001135
DR   CLO; CLO_0018771
DR   CLDB; cl24
DR   Coriell; GM16088
DR   ECACC; 90011862
DR   Wikidata; Q54582457
RX   PubMed=2400879;
RX   PubMed=7882314;
RX   PubMed=8609460;
RX   PubMed=9426062;
RX   PubMed=10395545;
RX   PubMed=15574327;
RX   PubMed=19896956;
CC   Characteristics: Radiosensitive cell line defective in DSB repair.
CC   Doubling time: 57 hours (PubMed=8609460).
CC   Sequence variation: Mutation; HGNC; 6601; LIG4; Simple; p.Arg278His (c.833G>A); ClinVar=VCV000007675; Zygosity=Unspecified (PubMed=10395545).
CC   Derived from site: In situ; Arm, skin; UBERON=UBERON_0002427.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C122657; LIG4 syndrome
DI   ORDO; Orphanet_99812; LIG4 syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   15Y
CA   Finite cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 14
//
RX   PubMed=2400879; DOI=10.1259/0007-1285-63-752-624;
RA   Plowman P.N., Bridges B.A., Arlett C.F., Hinney A., Kingston J.E.;
RT   "An instance of clinical radiation morbidity and cellular
RT   radiosensitivity, not associated with ataxia-telangiectasia.";
RL   Br. J. Radiol. 63:624-628(1990).
//
RX   PubMed=7882314;
RA   Badie C., Iliakis G., Foray N., Alsbeih G.A., Pantellias G.E.,
RA   Okayasu R., Cheong N., Russell N.S., Begg A.C., Arlett C.F.,
RA   Malaise E.-P.;
RT   "Defective repair of DNA double-strand breaks and chromosome damage in
RT   fibroblasts from a radiosensitive leukemia patient.";
RL   Cancer Res. 55:1232-1234(1995).
//
RX   PubMed=8609460; DOI=10.1080/095530096146075;
RA   Alsbeih G.A., Fertil B., Arlett C.F., Malaise E.-P.;
RT   "High split-dose recovery in hypersensitive human fibroblasts: a case
RT   of induced radioresistance?";
RL   Int. J. Radiat. Biol. 69:225-239(1996).
//
RX   PubMed=9426062;
RA   Lu H., Song Q.-Z., Arlett C.F., Lavin M.F.;
RT   "The radiosensitive cell line 180BR is not defective in the major DNA
RT   damage-sensing proteins.";
RL   Cancer Res. 58:84-88(1998).
//
RX   PubMed=10395545; DOI=10.1016/S0960-9822(99)80311-X;
RA   Riballo E., Critchlow S.E., Teo S.-H., Doherty A.J., Priestley A.,
RA   Broughton B.C., Kysela B., Beamish H.J., Plowman N., Arlett C.F.,
RA   Lehmann A.R., Jackson S.P., Jeggo P.A.;
RT   "Identification of a defect in DNA ligase IV in a radiosensitive
RT   leukaemia patient.";
RL   Curr. Biol. 9:699-702(1999).
//
RX   PubMed=15574327; DOI=10.1016/j.molcel.2004.10.029;
RA   Riballo E., Kuhne M., Rief N., Doherty A., Smith G.C.M., Recio M.-J.,
RA   Reis C., Dahm K., Fricke A., Krempler A., Parker A.R., Jackson S.P.,
RA   Gennery A.R., Jeggo P.A., Lobrich M.;
RT   "A pathway of double-strand break rejoining dependent upon ATM,
RT   Artemis, and proteins locating to gamma-H2AX foci.";
RL   Mol. Cell 16:715-724(2004).
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RX   PubMed=19896956; DOI=10.1016/j.mrfmmm.2009.10.013;
RA   Wilson P.F., Nham P.B., Urbin S.S., Hinz J.M., Jones I.M.,
RA   Thompson L.H.;
RT   "Inter-individual variation in DNA double-strand break repair in human
RT   fibroblasts before and after exposure to low doses of ionizing
RT   radiation.";
RL   Mutat. Res. 683:91-97(2010).
//