ID   HLF-a
AC   CVCL_2255
SY   HLFa; HLFA
DR   CLO; CLO_0003783
DR   CLDB; cl1699
DR   ArrayExpress; E-MTAB-2770
DR   ATCC; CCL-199
DR   BioSample; SAMN03471463
DR   BioSample; SAMN10988274
DR   cancercelllines; CVCL_2255
DR   Cell_Model_Passport; SIDM01710
DR   DepMap; ACH-000797
DR   ECACC; 90112703
DR   GEO; GSM206505
DR   GEO; GSM274805
DR   GEO; GSM274806
DR   GEO; GSM887085
DR   GEO; GSM888155
DR   IARC_TP53; 30040
DR   LiGeA; CCLE_508
DR   PharmacoDB; HLFa_550_2019
DR   Progenetix; CVCL_2255
DR   Wikidata; Q54889851
RX   DOI=10.1101/166199;
RX   PubMed=7065527;
RX   PubMed=22460905;
RX   PubMed=24002593;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Problematic cell line: Misclassified. Originally thought to be a lung squamous cell carcinoma cell line but using a variety of omics methods was shown to be a a fibroblastic cell line (DOI=10.1101/166199; DepMap).
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: African American.
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=90.86%; Native American=0%; East Asian, North=2.07%; East Asian, South=0%; South Asian=0%; European, North=1.99%; European, South=5.07% (PubMed=30894373).
CC   Discontinued: ECACC; 90112703; probable.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
ST   Source(s): ATCC
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 11,12
ST   D16S539: 12,13
ST   D5S818: 8,12
ST   D7S820: 9,12
ST   TH01: 6,9.3
ST   TPOX: 6,8
ST   vWA: 15
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   54Y
CA   Undefined cell line type
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 26
//
RX   DOI=10.1101/166199;
RA   de Weck A., Bitter H., Kauffmann A.;
RT   "Fibroblasts cell lines misclassified as cancer cell lines.";
RL   bioRxiv 2017:166199-166199(2017).
//
RX   PubMed=7065527; DOI=10.1164/arrd.1982.125.2.222;
RA   Hay R.J., Williams C.D., Macy M.L., Lavappa K.S.;
RT   "Cultured cell lines for research on pulmonary physiology available
RT   through the American Type Culture Collection.";
RL   Am. Rev. Respir. Dis. 125:222-232(1982).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=24002593; DOI=10.1038/bjc.2013.452;
RA   Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.;
RT   "Gene-expression data integration to squamous cell lung cancer
RT   subtypes reveals drug sensitivity.";
RL   Br. J. Cancer 109:1599-1608(2013).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//