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Cellosaurus UPCI-SCC-099 (CVCL_2225)

[Text version]
Cell line name UPCI-SCC-099
Synonyms UPCI:SCC099; SCC099
Accession CVCL_2225
Resource Identification Initiative To cite this cell line use: UPCI-SCC-099 (RRID:CVCL_2225)
Comments Doubling time: ~50 hours (DSMZ=ACC-665).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Caution: While the tumor has been shown to be HPV16 positive (PubMed=17112776), the cell line seems to be HPV16 negative (DSMZ=ACC-665).
Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
Sequence variations
Disease Floor of mouth squamous cell carcinoma (NCIt: C4041)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-665

Markers:
AmelogeninX
CSF1PO11,12
D2S133818
D3S135816
D5S81811,12
D7S8207,9,10
D8S117913
D13S3178,13
D16S53911,12
D18S5113
D19S43314,16
D21S1128
FGA23,23.2
Penta D9
Penta E7,8
TH016,9.3
TPOX11
vWA14,18,19

Run an STR similarity search on this cell line
Publications

PubMed=12872257; DOI=10.1002/humu.10248
Telmer C.A., An J.-Y., Malehorn D.E., Zeng X.-M., Gollin S.M., Ishwad C.S., Jarvik J.W.
Detection and assignment of TP53 mutations in tumor DNA using peptide mass signature genotyping.
Hum. Mutat. 22:158-165(2003)

PubMed=17112776; DOI=10.1016/j.oraloncology.2006.09.001; PMCID=PMC2025692
White J.S., Weissfeld J.L., Ragin C.C.R., Rossie K.M., Martin C.L., Shuster M., Ishwad C.S., Law J.C., Myers E.N., Johnson J.T., Gollin S.M.
The influence of clinical and demographic risk factors on the establishment of head and neck squamous cell carcinoma cell lines.
Oral Oncol. 43:701-712(2007)

PubMed=17681875; DOI=10.1016/j.oraloncology.2007.05.003; PMCID=PMC2362065
Martin C.L., Reshmi S.C., Ried T., Gottberg W., Wilson J.W., Reddy J.K., Khanna P., Johnson J.T., Myers E.N., Gollin S.M.
Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature.
Oral Oncol. 44:369-382(2008)

PubMed=24142626; DOI=10.1002/gcc.22115; PMCID=PMC5520977
Parikh R.A., Appleman L.J., Bauman J.E., Sankunny M., Lewis D.W., Vlad A., Gollin S.M.
Upregulation of the ATR-CHEK1 pathway in oral squamous cell carcinomas.
Genes Chromosomes Cancer 53:25-37(2014)

Cross-references
Cell line collections (Providers) DSMZ; ACC-665
Cell line databases/resources cancercelllines; CVCL_2225
DSMZCellDive; ACC-665
Biological sample resources BioSample; SAMN03473479
Encyclopedic resources Wikidata; Q54991660
Polymorphism and mutation databases IARC_TP53; 18358
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number22