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Cellosaurus U-HO1 (CVCL_2220)

[Text version]
Cell line name U-HO1
Synonyms U-H01; UHO1
Accession CVCL_2220
Resource Identification Initiative To cite this cell line use: U-HO1 (RRID:CVCL_2220)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: ~4 days (PubMed=18253030); ~100 hours (DSMZ=ACC-626).
Omics: SNP array analysis.
Anecdotal: Andreas Mader, the first author of the paper (PubMed=18253030) describing this cell line is the patient that donated the cell line. As it is not frequent to see a patient 'acknowledged' by being an author this fact should be emphasized.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 9642; PTPN1; Unexplicit; Ex2-8del; Zygosity=Unspecified (CelloPub=CLPUB00457).
  • Gene deletion; HGNC; 11896; TNFAIP3; Zygosity=Heterozygous (PubMed=19380639).
  • Mutation; HGNC; 11896; TNFAIP3; Simple; p.Met43fs (c.127-134del) (del 193-200); Zygosity=Heterozygous (PubMed=19380639).
Disease Hodgkin lymphoma (NCIt: C9357)
Hodgkin lymphoma (ORDO: Orphanet_98293)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UI40 (U-HO1-PTPN1)
Sex of cell Male
Age at sampling 23Y
Category Cancer cell line
STR profile Source(s): DepMap; DSMZ

Markers:
AmelogeninX,Y
CSF1PO10
D2S133823,24
D3S135813,17
D5S81811
D7S8208,10
D8S117913,16
D13S31711,12
D16S53911,13
D18S5114
D19S43313,14
D21S1130,32.2
FGA21,24
Penta D9,13
Penta E5,18
TH017,9.3
TPOX8,10
vWA18

Run an STR similarity search on this cell line
Publications

CLPUB00457
Wegener S., Mader A., Melzner I., Bruderlein S., Moller P.
Lack of PTPN1 (PTP1B) in U-HO1, a new Hodgkin-derived cell line, protects cells from apoptosis.
Haematologica 92 Suppl. 5:39-39(2007)

PubMed=18253030; DOI=10.1159/000112062
Mader A., Bruderlein S., Wegener S., Melzner I., Popov S., Muller-Hermelink H.-K., Barth T.F.E., Viardot A., Moller P.
U-HO1, a new cell line derived from a primary refractory classical Hodgkin lymphoma.
Cytogenet. Genome Res. 119:204-210(2007)

PubMed=18820924; DOI=10.1007/s00292-008-1055-6
Moller P., Mader A., Barth T.F.E., Bruderlein S.
U-HO1. A new cell line derived from a primary refractory classical Hodgkin lymphoma.
Pathologe 29:317-318(2008)

PubMed=19380639; DOI=10.1084/jem.20090528
Schmitz R., Hansmann M.-L., Bohle V., Martin-Subero J.I., Hartmann S., Mechtersheimer G., Klapper W., Vater I., Giefing M., Gesk S., Stanelle J., Siebert R., Kuppers R.
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.
J. Exp. Med. 206:981-989(2009)

PubMed=21144060; DOI=10.1186/1471-2121-11-99
Knecht H., Bruderlein S., Wegener S., Lichtensztejn D., Lichtensztejn Z., Lemieux B., Moller P., Mai S.
3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including 't-stumps'.
BMC Cell Biol. 11:99.1-99.10(2010)

PubMed=29533902; DOI=10.1515/hsz-2017-0321
Drexler H.G., Pommerenke C., Eberth S., Nagel S.
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.
Biol. Chem. 399:511-523(2018)

Cross-references
Cell line collections (Providers) DSMZ; ACC-626
Cell line databases/resources cancercelllines; CVCL_2220
Cell_Model_Passport; SIDM01831
DepMap; ACH-001685
DSMZCellDive; ACC-626
IGRhCellID; U-HO1
Biological sample resources BioSample; SAMN03473507
Encyclopedic resources Wikidata; Q54973621
Gene expression databases GEO; GSM381299
Polymorphism and mutation databases Cosmic; 1289702
Cosmic; 1432042
Progenetix; CVCL_2220
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number28