ID   RS-5
AC   CVCL_2182
SY   RS5
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN03473499
DR   BioSample; SAMN10988436
DR   cancercelllines; CVCL_2182
DR   Cell_Model_Passport; SIDM01772
DR   DepMap; ACH-000531
DR   DSMZ; ACC-604
DR   DSMZCellDive; ACC-604
DR   IARC_TP53; 30153
DR   LiGeA; CCLE_175
DR   PharmacoDB; RS5_1330_2019
DR   Wikidata; Q54951295
RX   DOI=10.1101/166199;
RX   PubMed=15372243;
RX   PubMed=26589293;
RX   PubMed=31068700;
CC   Problematic cell line: May be misclassified. While still annotated as a pleural sarcomatoid mesothelioma cell line, a variety of omics methods are classifying this cell line as a fibroblast (DOI=10.1101/166199; DepMap).
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Doubling time: ~4 days (DSMZ=ACC-604).
CC   HLA typing: A*02:01,11:01; B*35:01,44:02; C*04:01,07:04; DQA1*01:02,05:02; DQB1*05:01,05:01; DRB1*11:02,14:46 (PubMed=26589293).
CC   Omics: Transcriptome analysis by RNAseq.
CC   Caution: Not directly described in the original publication, but indirectly mentioned ('Three others cell lines progressed in tissue culture') (PubMed=15372243).
ST   Source(s): DSMZ
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 11,12
ST   D16S539: 11,12
ST   D18S51: 13,17
ST   D19S433: 13,14
ST   D21S11: 30,32.2
ST   D2S1338: 19,22
ST   D3S1358: 14,15
ST   D5S818: 12,13
ST   D7S820: 9,11
ST   D8S1179: 12,13
ST   FGA: 21
ST   Penta D: 12
ST   Penta E: 5,16
ST   TH01: 7,10
ST   TPOX: 9,10
ST   vWA: 17
DI   NCIt; C45663; Pleural sarcomatoid mesothelioma
DI   ORDO; Orphanet_50251; Pleural mesothelioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   78Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 24
RX   DOI=10.1101/166199;
RA   de Weck A., Bitter H., Kauffmann A.;
RT   "Fibroblasts cell lines misclassified as cancer cell lines.";
RL   bioRxiv 2017:166199-166199(2017).
RX   PubMed=15372243; DOI=10.1007/s00418-004-0701-1;
RA   Philippeaux M.-M., Pache J.-C., Dahoun S., Barnet M., Robert J.-H.,
RA   Mauel J., Spiliopoulos A.;
RT   "Establishment of permanent cell lines purified from human
RT   mesothelioma: morphological aspects, new marker expression and
RT   karyotypic analysis.";
RL   Histochem. Cell Biol. 122:249-260(2004).
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).