ID   PLB-985
AC   CVCL_2162
SY   PLB 985; PLB985
DR   BTO; BTO_0002908
DR   CLO; CLO_0008457
DR   EFO; EFO_0002313
DR   CLDB; cl3912
DR   ArrayExpress; E-MTAB-38
DR   BioSample; SAMN03151776
DR   BioSample; SAMN10989584
DR   cancercelllines; CVCL_2162
DR   Cell_Model_Passport; SIDM00811
DR   Cosmic; 787475
DR   Cosmic; 1089520
DR   DepMap; ACH-000034
DR   DSMZ; ACC-139
DR   DSMZCellDive; ACC-139
DR   GEO; GSM1446750
DR   GEO; GSM2690922
DR   GEO; GSM2690923
DR   GEO; GSM2690924
DR   GEO; GSM2690925
DR   GEO; GSM2690926
DR   GEO; GSM2690927
DR   GEO; GSM2690928
DR   GEO; GSM2690929
DR   GEO; GSM2690930
DR   GEO; GSM2690931
DR   GEO; GSM2690932
DR   GEO; GSM2690933
DR   IGRhCellID; PLB985
DR   Lonza; 281
DR   Progenetix; CVCL_2162
DR   Wikidata; Q54947571
RX   PubMed=3475136;
RX   PubMed=8234321;
RX   PubMed=12592342;
RX   PubMed=20143388;
RX   PubMed=20215515;
RX   PubMed=25984343;
RX   PubMed=28287132;
RX   PubMed=29967760;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=36982453;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/p/cell-lines-detail-65.html
CC   Problematic cell line: Contaminated. Shown to be a HL-60 derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from a 38 year old female patient with acute nonlymphocytic leukemia.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00258.
CC   Population: Caucasian.
CC   Doubling time: 35 hours (PubMed=25984343); ~24 hours (DSMZ=ACC-139).
CC   Sequence variation: Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (DepMap=ACH-000034).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (DepMap=ACH-000034).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; shRNA library screening.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.99%; Native American=0%; East Asian, North=1.35%; East Asian, South=0%; South Asian=0%; European, North=69.55%; European, South=28.11% (PubMed=30894373).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): DSMZ=ACC-139
ST   Amelogenin: X
ST   CSF1PO: 13,14
ST   D13S317: 8,11
ST   D16S539: 11
ST   D18S51: 14,15
ST   D19S433: 14
ST   D21S11: 29,30
ST   D2S1338: 17
ST   D3S1358: 16
ST   D5S818: 12
ST   D7S820: 11,12
ST   D8S1179: 12
ST   FGA: 22,24
ST   Penta D: 10,11
ST   Penta E: 13,14
ST   TH01: 7,8
ST   TPOX: 8,11
ST   vWA: 16
DI   NCIt; C7961; Adult acute myeloid leukemia with maturation
DI   ORDO; Orphanet_98834; Acute myeloblastic leukemia with maturation
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0002 ! HL-60
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 38
CH   CVCL_C3HD ! PLB-985 CYBB KO
CH   CVCL_C8HI ! PLB-985 NCF1 DeltaGT
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=29967760; DOI=10.3389/fonc.2018.00218; PMCID=PMC6015904;
RA   Kiffin, Roberta
RA   Wiktorin, Hanna Grauers
RA   Nilsson, Malin S.
RA   Aurelius, Johan
RA   Aydin, Ebru
RA   Lenox, Brianna
RA   Nilsson, Jonas A.
RA   Stahlberg, Anders
RA   Thoren, Fredrik Bergh
RA   Hellstrand, Kristoffer
RA   Martner, Anna
RT   "Anti-leukemic properties of histamine in monocytic leukemia: the role
RT   of NOX2.";
RL   Front. Oncol. 8:218.1-218.12(2018).
//
RX   PubMed=8234321; DOI=10.1073/pnas.90.21.9832; PMCID=PMC47666;
RA   Zhen, Ling
RA   King, Alexandra A.J.
RA   Xiao, Yong-Hong
RA   Chanock, Stephen Jacob
RA   Orkin, Stuart Holland
RA   Dinauer, Mary C.
RT   "Gene targeting of X chromosome-linked chronic granulomatous disease
RT   locus in a human myeloid leukemia cell line and rescue by expression
RT   of recombinant gp91phox.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:9832-9836(1993).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=28287132; DOI=10.1038/srep44187; PMCID=PMC5347011;
RA   Wrona, Dominik
RA   Siler, Ulrich
RA   Reichenbach, Janine
RT   "CRISPR/Cas9-generated p47(phox)-deficient cell line for chronic
RT   granulomatous disease gene therapy vector development.";
RL   Sci. Rep. 7:44187.1-44187.6(2017).
//
RX   PubMed=12592342; DOI=10.1038/sj.leu.2402799;
RA   Drexler, Hans Gunther
RA   Dirks, Wilhelm Gerhard
RA   Matsuo, Yoshinobu
RA   MacLeod, Roderick A.F.
RT   "False leukemia-lymphoma cell lines: an update on over 500 cell
RT   lines.";
RL   Leukemia 17:416-426(2003).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652;
RA   Cowley, Glenn S.
RA   Weir, Barbara A.
RA   Vazquez, Francisca
RA   Tamayo, Pablo
RA   Scott, Justine A.
RA   Rusin, Scott
RA   East-Seletsky, Alexandra
RA   Ali, Levi D.
RA   Gerath, William F.J.
RA   Pantel, Sarah E.
RA   Lizotte, Patrick Hall
RA   Jiang, Guo-Zhi
RA   Hsiao, Jessica
RA   Tsherniak, Aviad
RA   Dwinell, Elizabeth
RA   Aoyama, Simon
RA   Okamoto, Michael
RA   Harrington, William
RA   Gelfand, Ellen T.
RA   Green, Thomas M.
RA   Tomko, Mark J.
RA   Gopal, Shuba
RA   Wong, Terence C.
RA   Li, Hu-Bo
RA   Howell, Sara
RA   Stransky, Nicolas
RA   Liefeld, Ted
RA   Jang, Dongkeun
RA   Bistline, Jonathan
RA   Meyers, Barbara Hill
RA   Armstrong, Scott Allen
RA   Anderson, Kenneth Carl
RA   Stegmaier, Kimberly
RA   Reich, Michael
RA   Pellman, David
RA   Boehm, Jesse S.
RA   Mesirov, Jill P.
RA   Golub, Todd Robert
RA   Root, David E.
RA   Hahn, William Chun
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035.1-140035.12(2014).
//
RX   PubMed=3475136; DOI=10.1182/blood.V70.2.372.372;
RA   Tucker, Kent A.
RA   Lilly, Michael Brian
RA   Heck, Louis Jr.
RA   Rado, Thomas A.
RT   "Characterization of a new human diploid myeloid leukemia cell line
RT   (PLB-985) with granulocytic and monocytic differentiating capacity.";
RL   Blood 70:372-378(1987).
//
RX   PubMed=36982453; DOI=10.3390/ijms24065377; PMCID=PMC10049680;
RA   Skopek, Rafal
RA   Palusinska, Malgorzata
RA   Kaczor-Keller, Katarzyna
RA   Pingwara, Rafal
RA   Papierniak-Wygladala, Anna
RA   Schenk, Tino
RA   Lewicki, Slawomir
RA   Zelent, Artur
RA   Szymanski, Lukasz
RT   "Choosing the right cell line for acute myeloid leukemia (AML)
RT   research.";
RL   Int. J. Mol. Sci. 24:5377.1-5377.34(2023).
//