ID MT-3 [Human contaminated breast cancer] AC CVCL_2129 SY MT3 DR CLO; CLO_0007890 DR EFO; EFO_0002241 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-2706 DR BioSample; SAMN03472975 DR BioSample; SAMN03473582 DR BioSample; SAMN06481118 DR cancercelllines; CVCL_2129 DR DSMZ; ACC-403 DR DSMZCellDive; ACC-403 DR EGA; EGAS00001000610 DR GEO; GSM115102 DR GEO; GSM217592 DR GEO; GSM412073 DR GEO; GSM412084 DR GEO; GSM412093 DR GEO; GSM412098 DR GEO; GSM412106 DR GEO; GSM412110 DR GEO; GSM459700 DR GEO; GSM474280 DR GEO; GSM474281 DR GEO; GSM476484 DR GEO; GSM476485 DR GEO; GSM478311 DR GEO; GSM478312 DR GEO; GSM478314 DR GEO; GSM478315 DR GEO; GSM478320 DR GEO; GSM478321 DR GEO; GSM783977 DR GEO; GSM844610 DR GEO; GSM847419 DR GEO; GSM847498 DR GEO; GSM1172986 DR IGRhCellID; MT3 DR LINCS_HMS; 50031 DR LINCS_LDP; LCL-1473 DR PharmacoDB; MT3_969_2019 DR Progenetix; CVCL_2129 DR Wikidata; Q54906937 RX PubMed=1446057; RX PubMed=9150904; RX PubMed=11044355; RX PubMed=12661003; RX PubMed=12800145; RX PubMed=15677628; RX PubMed=20215515; RX PubMed=24176112; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=28196595; WW Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx WW Info; MCLP; -; https://tcpaportal.org/mclp/ WW Info; Pawefish; -; https://www.cellosaurus.org/pawefish/BreastCellLineDescriptions/MT-3.html CC Problematic cell line: Contaminated. Shown to be a LS174T derivative (PubMed=25877200; DSMZ). Originally thought to originate from a breast carcinoma. CC Part of: MD Anderson Cell Lines Project. CC Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00506. CC Population: Caucasian. CC Doubling time: 37.1 +- 8.1 hours (PubMed=9150904); ~30 hours (DSMZ=ACC-403). CC HLA typing: A*02:01,02:01; B*07:17,15:50; C*04:01,06:02 (PubMed=26589293). CC Microsatellite instability: Instable (MSI) (PubMed=12661003; PubMed=15677628). CC Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line). CC Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line). CC Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line). CC Omics: Genomics; Whole exome sequencing. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Discontinued: DSMZ; ACC-403; true. CC Derived from site: In situ; Colon; UBERON=UBERON_0001155. CC Cell type: Epithelial cell of colon; CL=CL_0011108. ST Source(s): DSMZ=ACC-403; PubMed=25877200 ST Amelogenin: X ST CSF1PO: 10,13 ST D13S317: 10,11 ST D16S539: 11,13 ST D18S51: 10,12 ST D19S433: 13,14 ST D21S11: 29,31 ST D2S1338: 18,22 ST D3S1358: 15,16 ST D5S818: 12 (PubMed=25877200) ST D5S818: 12,17 (DSMZ=ACC-403) ST D7S820: 10.3,11,12 ST D8S1179: 12,15 (PubMed=25877200) ST D8S1179: 13,15 (DSMZ=ACC-403) ST FGA: 20,21 ST Penta D: 9,10 ST Penta E: 13,15 (PubMed=25877200) ST Penta E: 13,15,17,21 (DSMZ=ACC-403) ST TH01: 6,7 ST TPOX: 8,9 ST vWA: 13,14,16,17 (DSMZ=ACC-403) ST vWA: 14,17 (PubMed=25877200) DI NCIt; C4349; Colon adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) HI CVCL_1384 ! LS174T SX Female AG 58Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 36 // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=11044355; DOI=10.1054/bjoc.2000.1458; PMCID=PMC2408781; RA Davidson, Jeffrey M. RA Gorringe, Kylie Louise RA Chin, Suet-Feung RA Orsetti, Beatrice RA Besret, C. RA Courtay-Cahen, Celine RA Roberts, Ian RA Theillet, Charles RA Caldas, Carlos RA Edwards, Paul A.W. RT "Molecular cytogenetic analysis of breast cancer cell lines."; RL Br. J. Cancer 83:1309-1317(2000). // RX PubMed=12800145; DOI=10.1002/gcc.10218; RA Adelaide, Jose RA Huang, Huai-En RA Murati, Anne RA Alsop, Amber E. RA Orsetti, Beatrice RA Mozziconacci, Marie-Joelle RA Popovici, Cornel RA Ginestier, Christophe RA Letessier, Anne RA Basset, Celine RA Courtay-Cahen, Celine RA Jacquemier, Jocelyne RA Theillet, Charles RA Birnbaum, Daniel RA Edwards, Paul A.W. RA Chaffanet, Max RT "A recurrent chromosome translocation breakpoint in breast and RT pancreatic cancer cell lines targets the neuregulin/NRG1 gene."; RL Genes Chromosomes Cancer 37:333-345(2003). // RX PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590; RA Daemen, Anneleen RA Griffith, Obi L. RA Heiser, Laura M. RA Wang, Nicholas J. RA Enache, Oana M. RA Sanborn, Zachary J. RA Pepin, Francois RA Durinck, Steffen RA Korkola, James E. RA Griffith, Malachi RA Hur, Joe S. RA Huh, Nam RA Chung, Jongsuk RA Cope, Leslie RA Fackler, Mary Jo RA Umbricht, Christopher Benedict RA Sukumar, Saraswati RA Seth, Pankaj RA Sukhatme, Vikas P. RA Jakkula, Lakshmi R. RA Lu, Yi-Ling RA Mills, Gordon B. RA Cho, Raymond J. RA Collisson, Eric A. RA van 't Veer, Laura J. RA Spellman, Paul T. RA Gray, Joe W. RT "Modeling precision treatment of breast cancer."; RL Genome Biol. 14:R110.1-R110.14(2013). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li, Jun RA Zhao, Wei RA Akbani, Rehan RA Liu, Wen-Bin RA Ju, Zhen-Lin RA Ling, Shi-Yun RA Vellano, Christopher P. RA Roebuck, Paul RA Yu, Qing-Hua RA Eterovic, Agda Karina RA Byers, Lauren Averett RA Davies, Michael A. RA Deng, Wan-Leng RA Gopal, Y.N. Vashisht RA Chen, Guo RA von Euw, Erika Maria RA Slamon, Dennis Joseph RA Conklin, Dylan RA Heymach, John Victor RA Gazdar, Adi F. RA Minna, John D. RA Myers, Jeffrey N. RA Lu, Yi-Ling RA Mills, Gordon B. RA Liang, Han RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=9150904; DOI=10.1023/A:1005756632293; RA Hambly, Richard J. RA Double, John A. RA Thompson, Michael J. RA Bibby, Michael C. RT "Establishment and characterisation of new cell lines from human RT breast tumours initially established as tumour xenografts in NMRI nude RT mice."; RL Breast Cancer Res. Treat. 43:247-258(1997). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=15677628; DOI=10.1093/carcin/bgi032; RA Gorringe, Kylie Louise RA Chin, Suet-Feung RA Pharoah, Paul D.P. RA Staines, Joanne M. RA Oliveira, Carla RA Edwards, Paul A.W. RA Caldas, Carlos RT "Evidence that both genetic instability and selection contribute to RT the accumulation of chromosome alterations in cancer."; RL Carcinogenesis 26:923-930(2005). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=1446057; DOI=10.1007/BF01831480; RA Naundorf, Helga RA Rewasowa, E.C. RA Fichtner, Iduna RA Buttner, Britta RA Becker, Michael RA Gorlich, Max RT "Characterization of two human mammary carcinomas, MT-1 and MT-3, RT suitable for in vivo testing of ether lipids and their derivatives."; RL Breast Cancer Res. Treat. 23:87-95(1992). // RX PubMed=12661003; DOI=10.1002/gcc.10196; RA Seitz, Susanne RA Wassmuth, Peter RA Plaschke, Jens RA Schackert, Hans Konrad RA Karsten, Uwe RA Santibanez-Koref, Mauro F. RA Schlag, Peter Michael RA Scherneck, Siegfried RT "Identification of microsatellite instability and mismatch repair gene RT mutations in breast cancer cell lines."; RL Genes Chromosomes Cancer 37:29-35(2003). //