ID   MT-3 [Human contaminated breast cancer]
AC   CVCL_2129
SY   MT3
DR   CLO; CLO_0007890
DR   EFO; EFO_0002241
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-2706
DR   BioSample; SAMN03472975
DR   BioSample; SAMN03473582
DR   BioSample; SAMN06481118
DR   cancercelllines; CVCL_2129
DR   DSMZ; ACC-403
DR   DSMZCellDive; ACC-403
DR   EGA; EGAS00001000610
DR   GEO; GSM115102
DR   GEO; GSM217592
DR   GEO; GSM412073
DR   GEO; GSM412084
DR   GEO; GSM412093
DR   GEO; GSM412098
DR   GEO; GSM412106
DR   GEO; GSM412110
DR   GEO; GSM459700
DR   GEO; GSM474280
DR   GEO; GSM474281
DR   GEO; GSM476484
DR   GEO; GSM476485
DR   GEO; GSM478311
DR   GEO; GSM478312
DR   GEO; GSM478314
DR   GEO; GSM478315
DR   GEO; GSM478320
DR   GEO; GSM478321
DR   GEO; GSM783977
DR   GEO; GSM844610
DR   GEO; GSM847419
DR   GEO; GSM847498
DR   GEO; GSM1172986
DR   IGRhCellID; MT3
DR   LINCS_HMS; 50031
DR   LINCS_LDP; LCL-1473
DR   PharmacoDB; MT3_969_2019
DR   Progenetix; CVCL_2129
DR   Wikidata; Q54906937
RX   PubMed=1446057;
RX   PubMed=9150904;
RX   PubMed=11044355;
RX   PubMed=12661003;
RX   PubMed=12800145;
RX   PubMed=15677628;
RX   PubMed=20215515;
RX   PubMed=24176112;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=28196595;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
WW   Info; Pawefish; -; https://www.cellosaurus.org/pawefish/BreastCellLineDescriptions/MT-3.html
CC   Problematic cell line: Contaminated. Shown to be a LS174T derivative (PubMed=25877200; DSMZ). Originally thought to originate from a breast carcinoma.
CC   Part of: MD Anderson Cell Lines Project.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00506.
CC   Population: Caucasian.
CC   Doubling time: 37.1 +- 8.1 hours (PubMed=9150904); ~30 hours (DSMZ=ACC-403).
CC   HLA typing: A*02:01,02:01; B*07:17,15:50; C*04:01,06:02 (PubMed=26589293).
CC   Microsatellite instability: Instable (MSI) (PubMed=12661003; PubMed=15677628).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Discontinued: DSMZ; ACC-403; true.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
ST   Source(s): DSMZ=ACC-403; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10,13
ST   D13S317: 10,11
ST   D16S539: 11,13
ST   D18S51: 10,12
ST   D19S433: 13,14
ST   D21S11: 29,31
ST   D2S1338: 18,22
ST   D3S1358: 15,16
ST   D5S818: 12 (PubMed=25877200)
ST   D5S818: 12,17 (DSMZ=ACC-403)
ST   D7S820: 10.3,11,12
ST   D8S1179: 12,15 (PubMed=25877200)
ST   D8S1179: 13,15 (DSMZ=ACC-403)
ST   FGA: 20,21
ST   Penta D: 9,10
ST   Penta E: 13,15 (PubMed=25877200)
ST   Penta E: 13,15,17,21 (DSMZ=ACC-403)
ST   TH01: 6,7
ST   TPOX: 8,9
ST   vWA: 13,14,16,17 (DSMZ=ACC-403)
ST   vWA: 14,17 (PubMed=25877200)
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1384 ! LS174T
SX   Female
AG   58Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 36
//
RX   PubMed=1446057; DOI=10.1007/BF01831480;
RA   Naundorf, Helga
RA   Rewasowa, E.C.
RA   Fichtner, Iduna
RA   Buttner, Britta
RA   Becker, Michael
RA   Gorlich, Max
RT   "Characterization of two human mammary carcinomas, MT-1 and MT-3,
RT   suitable for in vivo testing of ether lipids and their derivatives.";
RL   Breast Cancer Res. Treat. 23:87-95(1992).
//
RX   PubMed=9150904; DOI=10.1023/A:1005756632293;
RA   Hambly, Richard J.
RA   Double, John A.
RA   Thompson, Michael J.
RA   Bibby, Michael C.
RT   "Establishment and characterisation of new cell lines from human
RT   breast tumours initially established as tumour xenografts in NMRI nude
RT   mice.";
RL   Breast Cancer Res. Treat. 43:247-258(1997).
//
RX   PubMed=11044355; DOI=10.1054/bjoc.2000.1458; PMCID=PMC2408781;
RA   Davidson, Jeffrey M.
RA   Gorringe, Kylie Louise
RA   Chin, Suet-Feung
RA   Orsetti, Beatrice
RA   Besret, C.
RA   Courtay-Cahen, Celine
RA   Roberts, Ian
RA   Theillet, Charles
RA   Caldas, Carlos
RA   Edwards, Paul A.W.
RT   "Molecular cytogenetic analysis of breast cancer cell lines.";
RL   Br. J. Cancer 83:1309-1317(2000).
//
RX   PubMed=12661003; DOI=10.1002/gcc.10196;
RA   Seitz, Susanne
RA   Wassmuth, Peter
RA   Plaschke, Jens
RA   Schackert, Hans Konrad
RA   Karsten, Uwe
RA   Santibanez-Koref, Mauro F.
RA   Schlag, Peter Michael
RA   Scherneck, Siegfried
RT   "Identification of microsatellite instability and mismatch repair gene
RT   mutations in breast cancer cell lines.";
RL   Genes Chromosomes Cancer 37:29-35(2003).
//
RX   PubMed=12800145; DOI=10.1002/gcc.10218;
RA   Adelaide, Jose
RA   Huang, Huai-En
RA   Murati, Anne
RA   Alsop, Amber E.
RA   Orsetti, Beatrice
RA   Mozziconacci, Marie-Joelle
RA   Popovici, Cornel
RA   Ginestier, Christophe
RA   Letessier, Anne
RA   Basset, Celine
RA   Courtay-Cahen, Celine
RA   Jacquemier, Jocelyne
RA   Theillet, Charles
RA   Birnbaum, Daniel
RA   Edwards, Paul A.W.
RA   Chaffanet, Max
RT   "A recurrent chromosome translocation breakpoint in breast and
RT   pancreatic cancer cell lines targets the neuregulin/NRG1 gene.";
RL   Genes Chromosomes Cancer 37:333-345(2003).
//
RX   PubMed=15677628; DOI=10.1093/carcin/bgi032;
RA   Gorringe, Kylie Louise
RA   Chin, Suet-Feung
RA   Pharoah, Paul D.P.
RA   Staines, Joanne M.
RA   Oliveira, Carla
RA   Edwards, Paul A.W.
RA   Caldas, Carlos
RT   "Evidence that both genetic instability and selection contribute to
RT   the accumulation of chromosome alterations in cancer.";
RL   Carcinogenesis 26:923-930(2005).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590;
RA   Daemen, Anneleen
RA   Griffith, Obi L.
RA   Heiser, Laura M.
RA   Wang, Nicholas J.
RA   Enache, Oana M.
RA   Sanborn, Zachary
RA   Pepin, Francois
RA   Durinck, Steffen
RA   Korkola, James E.
RA   Griffith, Malachi
RA   Hur, Joe S.
RA   Huh, Nam
RA   Chung, Jongsuk
RA   Cope, Leslie
RA   Fackler, Mary Jo
RA   Umbricht, Christopher Benedict
RA   Sukumar, Saraswati
RA   Seth, Pankaj
RA   Sukhatme, Vikas P.
RA   Jakkula, Lakshmi R.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Cho, Raymond J.
RA   Collisson, Eric A.
RA   van 't Veer, Laura J.
RA   Spellman, Paul T.
RA   Gray, Joe W.
RT   "Modeling precision treatment of breast cancer.";
RL   Genome Biol. 14:R110.1-R110.14(2013).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, A. Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//